Itagaki Tatsuki, Nakamura Keisuke, Tanabe Tougo, Shimura Takumi, Nakai Yu, Sakata Ken-Ichiro, Sato Jun, Kitagawa Yoshimasa
Department of Oral Diagnosis and Medicine, Faculty of Dental Medicine, Hokkaido University, Kita-13 Nishi-7, Kita-ku, Sapporo 060-8586, Japan.
Biomedicines. 2024 May 4;12(5):1013. doi: 10.3390/biomedicines12051013.
Burning mouth syndrome (BMS) is a chronic oral pain disorder. There is a theory that BMS is a form of nociplastic pain. A standard treatment for BMS has not yet been established. Kampo medicine is a traditional oriental medicine. The purpose of this study is to evaluate the effectiveness of Rikkosan-a traditional Japanese herbal medicine (Kampo)-in the treatment of BMS. A single-center retrospective study was conducted on 20 patients who were diagnosed with BMS and treated with Rikkosan alone (total daily dose; 7.5 g) three times daily for approximately 4 weeks (29.5 ± 6.5 days). Rikkosan was dissolved in hot water and taken internally. They had an average age of 63 years, and 90% were being treated for other illnesses, but their medication status was the same during this study period, except for Rikkosan. No adverse events were observed in patients. Numerical rating scale (NRS) or visual analog scale (VAS)/10 scores decreased significantly between the time of the initiation of Rikkosan and one month after (-2.1 ± 1.2, < 0.05). Rikkosan has a short-term effect of reducing NRS by two levels in BMS patients.
灼口综合征(BMS)是一种慢性口腔疼痛疾病。有一种理论认为,BMS是一种伤害性感受异常性疼痛。目前尚未确立BMS的标准治疗方法。汉方医学是一种传统的东方医学。本研究的目的是评估历节散(一种传统的日本草药(汉方))治疗BMS的有效性。对20例被诊断为BMS且仅接受历节散治疗(每日总剂量;7.5克)、每日三次、持续约4周(29.5±6.5天)的患者进行了单中心回顾性研究。历节散用热水溶解后内服。他们的平均年龄为63岁,90%的患者正在接受其他疾病的治疗,但在本研究期间,除历节散外,他们的用药情况相同。未观察到患者出现不良事件。在开始服用历节散时与服药后1个月之间,数字评定量表(NRS)或视觉模拟量表(VAS)/10分显著下降(-2.1±1.2,P<0.05)。历节散对BMS患者有使NRS降低两个等级的短期效果。