Brune K
Agents Actions Suppl. 1985;17:59-63. doi: 10.1007/978-3-0348-7720-6_7.
Even the most widely used non-steroidal anti-inflammatory drugs (NSAID's) show considerable variations in their pharmacokinetic behaviour in volunteers and moreso in patients. An evaluation of the response-related pharmacokinetic parameters of the three presently most widely used NSAID's, namely diclofenac, indomethacin and piroxicam shows some obvious reasons: While the onset of absorption and the bioavailability of diclofenac varies considerably, we find relevant differences in the terminal plasma half-life of indomethacin and particularly piroxicam. Inter-patient variability in these parameters may contribute significantly to the observed variations in clinical response.
即使是最广泛使用的非甾体抗炎药（NSAID）在志愿者中的药代动力学行为也存在相当大的差异，在患者中更是如此。对目前最广泛使用的三种NSAID（即双氯芬酸、吲哚美辛和吡罗昔康）的反应相关药代动力学参数进行评估，发现了一些明显的原因：虽然双氯芬酸的吸收起始和生物利用度差异很大，但我们发现吲哚美辛尤其是吡罗昔康的终末血浆半衰期存在相关差异。这些参数在患者间的变异性可能是导致观察到的临床反应差异的重要原因。
