Functional Food Division, National Institute of Agricultural Sciences, Rural Development Administration, Wanju 55365, Korea.
Division of Applied Food System, Major of Food and Nutrition, Seoul Women's University, Seoul 01797, Korea.
Nutrients. 2020 Jun 1;12(6):1631. doi: 10.3390/nu12061631.
Estrogen deficiency is associated with obesity, dyslipidemia, and increased insulin resistance in postmenopausal women. An efficient therapeutic agent prevents or improves postmenopausal conditions induced by estrogen deficiency. Here, we investigated the effects of aqueous Ledeb. extract on glucose and lipid metabolism in ovariectomized rats fed a high-fat diet (HFD). Female Sprague-Dawley rats were sham-operated or ovariectomized, and 3 weeks later were assigned to the following groups: sham-operated + HFD (S); ovariectomized + HFD (OVX); and ovariectomized + HFD with 0.5% aqueous extract (OVX + 0.5A) groups. Ovariectomy significantly increased body weight and dietary intake relative to the S group. However, treatment did not significantly affect weight gain or dietary intake. Blood triacylglycerol, total cholesterol, and low-density lipoprotein cholesterol levels tended to decrease in the -supplemented group. Blood glucose levels were significantly lower in the OVX + 0.5A group than those in the OVX group. Blood adiponectin and insulin concentrations increased significantly after treatment in the ovariectomized group. supplementation tended to decrease liver weights and prevented lipid accumulation. These effects correlated with reduced hepatic expression of lipogenesis-related genes (fatty acid synthase, acetyl-coenzyme A carboxylase alpha, and 3-hydroxy-3-methylglutaryl-coenzyme A reductase). Therefore, may improve metabolic disorders in ovariectomized rats.
雌激素缺乏与绝经后妇女的肥胖、血脂异常和胰岛素抵抗有关。一种有效的治疗剂可以预防或改善由雌激素缺乏引起的绝经后症状。在这里，我们研究了 Ledeb. 水提物对高脂饮食（HFD）喂养的去卵巢大鼠葡萄糖和脂质代谢的影响。雌性 Sprague-Dawley 大鼠接受假手术或去卵巢手术，3 周后分为以下几组：假手术+HFD（S）；去卵巢+HFD（OVX）；去卵巢+HFD+0.5%水提物（OVX+0.5A）。与 S 组相比，去卵巢显著增加了体重和饮食摄入量。然而，治疗并没有显著影响体重增加或饮食摄入。补充组的血液三酰甘油、总胆固醇和低密度脂蛋白胆固醇水平有降低的趋势。与 OVX 组相比，OVX+0.5A 组的血糖水平显著降低。去卵巢组经治疗后血液脂联素和胰岛素浓度显著升高。补充剂有降低肝脏重量和预防脂质积累的趋势。这些作用与脂生成相关基因（脂肪酸合酶、乙酰辅酶 A 羧化酶 alpha 和 3-羟-3-甲基戊二酰辅酶 A 还原酶）的肝表达减少有关。因此，Ledeb. 水提物可能改善去卵巢大鼠的代谢紊乱。
