Private Practice, Brussels, Belgium.
Am J Clin Dermatol. 2012 Dec 1;13(6):357-64. doi: 10.2165/11632500-000000000-00000.
The multifactorial etiology of acne vulgaris makes it challenging to treat. Current treatments include topical retinoids, benzoyl peroxide, topical and systemic antibiotics, azelaic acid, and systemic isotretinoin. Adjunctive and/or emerging approaches include topical dapsone, taurine bromamine, resveratrol, chemical peels, optical treatments, as well as complementary and alternative medications. The purpose of this paper is to discuss the therapies available for acne and their latest developments, including new treatment strategies (i.e. re-evaluation of the use of oral antibiotics and avoidance of topical antibiotic monotherapy, use of subantimicrobial antibiotic dosing, use of low-dose isotretinoin, optical treatments), new formulations (microsponges, liposomes, nanoemulsions, aerosol foams), new combinations (fixed-combination products of topical retinoids and topical antibiotics [essentially clindamycin] or benzoyl peroxide), new agents (topical dapsone, taurine bromamine, resveratrol) and their rationale and likely place in treatment. Acne vaccines, topical natural antimicrobial peptides, and lauric acid represent other promising therapies.
寻常痤疮的多因素病因使其治疗具有挑战性。目前的治疗方法包括局部维 A 酸、过氧化苯甲酰、局部和全身抗生素、壬二酸和全身异维 A 酸。辅助和/或新兴方法包括局部氨苯砜、牛磺酸溴胺、白藜芦醇、化学换肤、光疗以及补充和替代药物。本文旨在讨论痤疮的可用疗法及其最新进展，包括新的治疗策略（即重新评估口服抗生素的使用和避免局部抗生素单一疗法、使用亚抗菌剂量的抗生素、使用低剂量异维 A 酸、光疗）、新制剂（微海绵、脂质体、纳米乳液、气溶胶泡沫）、新组合（局部维 A 酸和局部抗生素[主要是克林霉素]或过氧化苯甲酰的固定组合产品）、新制剂（局部氨苯砜、牛磺酸溴胺、白藜芦醇）及其原理和在治疗中的可能位置。痤疮疫苗、局部天然抗菌肽和月桂酸代表了其他有前途的疗法。
