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在KOS-Zawał(MC-AMI)计划下康复的心肌梗死后患者身体成分变化的评估,包括相位角。

Evaluation of Change in Body Composition, including Phase Angle, in Post-Myocardial Infarction Patients Rehabilitated under the KOS-Zawał (MC-AMI) Programme.

作者信息

Ślązak Aleksandra, Przybylska Iga, Paprocka-Borowicz Małgorzata

机构信息

Department of Physiotherapy, Division of Musculoskeletal Rehabilitation, Wroclaw Medical University, 50-368 Wroclaw, Poland.

Department of Physiotherapy in Internal Medicine, Wroclaw University of Health and Sport Sciences, 51-612 Wroclaw, Poland.

出版信息

J Clin Med. 2024 May 9;13(10):2784. doi: 10.3390/jcm13102784.

Abstract

Ischaemic heart disease, including myocardial infarction, is one of the main causes leading to heart failure as a consequence of ischaemic myocardial damage. In recent years, survival in the acute phase of myocardial infarction has improved significantly, but the high mortality rate within 12 months of hospital discharge (reaching up to 9.8% in Poland) remains a challenge. Therefore, the KOS-Zawał (MC-AMI) comprehensive 12-month post-MI care programme was introduced in Poland in 2017. Aim: This study aimed to assess body composition (including, but not limited to, the phase angle, visceral fat, total body fat, redistribution between intracellular and extracellular fluid in the body, and metabolic age) using a bioelectrical impedance analysis (BIA) in post-MI patients before and after early post-MI rehabilitation who were participating in the KOS-Zawał (MC-AMI) programme. This study involved an examination (before rehabilitation) of 94 post-myocardial infarction patients who were referred to a cardiology appointment within 7-10 days of hospital discharge, during which a clinical assessment, electrocardiogram, and biochemical blood tests (complete blood count, CRP, and serum creatinine) were performed. For various reasons (death, qualification for device implantation, non-completion of rehabilitation, failure to attend a follow-up BIA), data from 55 patients who were examined twice (before and after rehabilitation) were used for the final analysis. Measurements were taken using a high-grade Tanita MC-780 BIA body composition analyser, which measured the resistance of tissues to a low-intensity electrical impulse (not perceptible to the subject). Participation in rehabilitation as part of the KOS-Zawał (MC-AMI) programme was associated with a decrease in metabolic age in patients, with a reduction in visceral fat levels and levels of adipose tissue in the lower and upper limbs. Moreover, a clinically beneficial reduction in the ratio of extracellular water to total body water was also observed. These changes were statistically significant ( < 0.005). In contrast, there were no statistically significant differences in the change in phase angle values in the subjects before and after the 5-week post-infarction rehabilitation. Participation in early post-myocardial infarction rehabilitation as part of the KOS-Zawał (MC-AMI) programme (25 training sessions) is associated with significant improvements in body composition parameters, such as visceral adipose tissue, limb fat, and water redistribution, and, consequently, a reduction in metabolic age, despite no significant increase in phase angle values. It was hypothesised that the good baseline condition of the subjects might explain the lack of significant change in the phase angle over the short observation period. For further analysis, it would be worthwhile to increase the number of patients with baseline reduced phase angle values and monitor changes in this parameter throughout rehabilitation and the entire MC-AMI programme, because changes in the phase angle may also be influenced by other programme components such as dietary or psychological education. It is worth considering implementing a regular BIA assessment in patients in the programme as a motivating stimulus for diligent exercise and extending rehabilitation to be followed by telerehabilitation or hybrid telerehabilitation.

摘要

缺血性心脏病,包括心肌梗死,是缺血性心肌损伤导致心力衰竭的主要原因之一。近年来,心肌梗死急性期的生存率有了显著提高,但出院后12个月内的高死亡率(在波兰高达9.8%)仍然是一个挑战。因此,2017年波兰推出了KOS-Zawał(MC-AMI)心肌梗死后12个月综合护理计划。目的:本研究旨在使用生物电阻抗分析(BIA)评估参与KOS-Zawał(MC-AMI)计划的心肌梗死后患者在心肌梗死后早期康复前后的身体成分(包括但不限于相位角、内脏脂肪、全身脂肪、体内细胞内液和细胞外液的重新分布以及代谢年龄)。本研究对94名心肌梗死后患者进行了检查(康复前),这些患者在出院后7至10天内被转介到心脏病科就诊,在此期间进行了临床评估、心电图和生化血液检查(全血细胞计数、CRP和血清肌酐)。由于各种原因(死亡、符合设备植入条件、未完成康复、未参加后续BIA检查),最终分析使用了55名接受两次检查(康复前后)患者的数据。测量使用高级Tanita MC-780 BIA身体成分分析仪进行,该仪器测量组织对低强度电脉冲(受试者无法感知)的电阻。作为KOS-Zawał(MC-AMI)计划一部分参与康复与患者代谢年龄的降低、内脏脂肪水平以及上下肢脂肪组织水平的降低相关。此外,还观察到细胞外水与全身水比例在临床上有益的降低。这些变化具有统计学意义(<0.005)。相比之下,梗死5周后康复前后受试者的相位角值变化没有统计学显著差异。作为KOS-Zawał(MC-AMI)计划一部分参与心肌梗死后早期康复(25次训练课程)与身体成分参数(如内脏脂肪组织、肢体脂肪和水分重新分布)的显著改善相关,因此代谢年龄降低,尽管相位角值没有显著增加。据推测,受试者良好的基线状况可能解释了在短观察期内相位角没有显著变化的原因。为了进一步分析,增加基线相位角值降低的患者数量并在整个康复过程和整个MC-AMI计划中监测该参数的变化是值得的,因为相位角的变化也可能受到其他计划组成部分(如饮食或心理教育)的影响。值得考虑在该计划的患者中定期进行BIA评估,作为激励他们勤奋锻炼的刺激措施,并将康复扩展到远程康复或混合远程康复。

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