Osaki Jordana Diniz, Oliveira Marco Aurelio Pinho
Núcleo Avançado de Endometriose e Robótica, Hospital DF Star, Brasília 70390-140, Brazil.
Department of Gynecology, State University of Rio de Janeiro, Rio de Janeiro 21941-617, Brazil.
J Clin Med. 2024 May 16;13(10):2927. doi: 10.3390/jcm13102927.
Endometriosis affects 10% of women worldwide. It is noteworthy that this condition is often accompanied by pelvic pain and stress. Endometriosis is a debilitating gynecological condition where tissue similar to the uterine lining grows outside the uterus, often causing significant pain and reproductive issues. We aimed to study the relationship between the intensity of pelvic pain, and stress and inflammatory markers in women with deep endometriosis. This cross-sectional study analyzed women diagnosed with deep endometriosis through imaging, surgery, and/or biopsy. We assessed pain using the Numerical Rating Scale (NRS). Stress was assessed with the Perceived Stress Scale (PSS-10) questionnaire and the serum cortisol levels. Additionally, we analyzed inflammatory markers, including C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Fifty-two women, with an average age of 37.8 ± 6.9 years, participated in this study. Forty-four percent of these participants demonstrated high levels of stress, as indicated by scores above 26 on the PSS-10. Those categorized with "high stress" on the PSS-10 questionnaire exhibited significantly higher pain levels compared to those with "low stress" ( < 0.05). Furthermore, patients experiencing more-severe pelvic pain (pain score > 7) had notably higher serum cortisol levels. Women with intense pelvic pain (scores above 7 on the NRS) had significantly elevated serum cortisol levels (Cohen's d = 0.72; = 0.018). A positive association was found between stress levels and the intensity of pelvic pain in women with deep endometriosis, suggesting an interconnection between emotional aspects and biological responses.
子宫内膜异位症影响着全球10%的女性。值得注意的是，这种病症常伴有盆腔疼痛和压力。子宫内膜异位症是一种使人虚弱的妇科疾病，在这种疾病中，类似于子宫内膜的组织在子宫外生长，常常导致严重的疼痛和生殖问题。我们旨在研究深部子宫内膜异位症女性盆腔疼痛强度与压力及炎症标志物之间的关系。这项横断面研究分析了通过影像学、手术和/或活检被诊断为深部子宫内膜异位症的女性。我们使用数字评分量表（NRS）评估疼痛。使用感知压力量表（PSS - 10）问卷和血清皮质醇水平评估压力。此外，我们分析了炎症标志物，包括C反应蛋白（CRP）和红细胞沉降率（ESR）。52名平均年龄为37.8±6.9岁的女性参与了本研究。这些参与者中，44%表现出高水平的压力，PSS - 10得分高于26分即表明这一点。在PSS - 10问卷中被归类为“高压力”的参与者与“低压力”参与者相比，疼痛水平显著更高（<0.05）。此外，经历更严重盆腔疼痛（疼痛评分>7）的患者血清皮质醇水平明显更高。盆腔疼痛剧烈（NRS评分高于7分）的女性血清皮质醇水平显著升高（科恩d值 = 0.72； = 0.
