Center for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA.
Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA.
Viruses. 2024 Apr 27;16(5):692. doi: 10.3390/v16050692.
Influenza viruses are constantly evolving and are therefore monitored worldwide in the hope to reduce the burden of disease by annual updates to vaccine recommendations. We conducted genomic sequencing of 110 influenza A and 30 influenza B viruses from specimens collected between October 2023 and February 2024 in Arizona, USA. We identified mutations in the hemagglutinin (HA) antigenic sites as well as the neuraminidase (NA) gene in our samples. We also found no unique HA and NA mutations in vaccinated yet influenza-infected individuals. Real-time genomic sequencing surveillance is important to ensure influenza vaccine effectiveness.
流感病毒不断进化，因此全球范围内对其进行监测，希望通过每年更新疫苗推荐来减轻疾病负担。我们对 2023 年 10 月至 2024 年 2 月在美国亚利桑那州采集的 110 株甲型流感病毒和 30 株乙型流感病毒的样本进行了基因组测序。我们在样本中发现了血凝素 (HA) 抗原位点以及神经氨酸酶 (NA) 基因的突变。我们还发现接种过疫苗但仍感染流感的个体中没有独特的 HA 和 NA 突变。实时基因组测序监测对于确保流感疫苗的有效性非常重要。
