Naskar Atanu, Kilari Sreenivasulu, Misra Sanjay
Vascular and Interventional Radiology Translational Laboratory, Division of Vascular and Interventional Radiology, Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Polymers (Basel). 2024 May 8;16(10):1327. doi: 10.3390/polym16101327.
Chitosan (CS) and two-dimensional nanomaterial (2D nanomaterials)-based scaffolds have received widespread attention in recent times in biomedical applications due to their excellent synergistic potential. CS has garnered much attention as a biomedical scaffold material either alone or in combination with some other material due to its favorable physiochemical properties. The emerging 2D nanomaterials, such as black phosphorus (BP), molybdenum disulfide (MoS), etc., have taken huge steps towards varying biomedical applications. However, the implementation of a CS-2D nanomaterial-based scaffold for clinical applications remains challenging for different reasons such as toxicity, stability, etc. Here, we reviewed different types of CS scaffold materials and discussed their advantages in biomedical applications. In addition, a different CS nanostructure, instead of a scaffold, has been described. After that, the importance of 2D nanomaterials has been elaborated on in terms of physiochemical properties. In the next section, the biomedical applications of CS with different 2D nanomaterial scaffolds have been highlighted. Finally, we highlighted the existing challenges and future perspectives of using CS-2D nanomaterial scaffolds for biomedical applications. We hope that this review will encourage a more synergistic biomedical application of the CS-2D nanomaterial scaffolds and their utilization clinical applications.
壳聚糖（CS）和基于二维纳米材料（2D纳米材料）的支架由于其优异的协同潜力，近年来在生物医学应用中受到广泛关注。CS因其良好的物理化学性质，作为生物医学支架材料单独使用或与其他一些材料结合使用时都备受关注。新兴的二维纳米材料，如黑磷（BP）、二硫化钼（MoS）等，在不同的生物医学应用方面取得了巨大进展。然而，由于毒性、稳定性等不同原因，基于CS-2D纳米材料的支架在临床应用中的实施仍然具有挑战性。在此，我们综述了不同类型的CS支架材料，并讨论了它们在生物医学应用中的优势。此外，还描述了一种不同的CS纳米结构，而不是支架。之后，从物理化学性质方面阐述了二维纳米材料的重要性。在下一节中，重点介绍了CS与不同二维纳米材料支架的生物医学应用。最后，我们强调了使用CS-2D纳米材料支架进行生物医学应用时存在的挑战和未来前景。我们希望这篇综述将促进CS-2D纳米材料支架在生物医学应用中的更协同应用及其在临床应用中的利用。
