Department of Pharmacy, Baghdad College of Medical Sciences, Baghdad, Iraq.
Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty 643001, The Nilgiris, India.
Int J Biol Macromol. 2024 Apr;264(Pt 2):130683. doi: 10.1016/j.ijbiomac.2024.130683. Epub 2024 Mar 6.
Nowadays, there is a wide range of deficiencies in treatment of diseases. These limitations are correlated with the inefficient ability of current modalities in the prognosis, diagnosis, and treatment of diseases. Therefore, there is a fundamental need for the development of novel approaches to overcome the mentioned restrictions. Chitosan (CS) nanoparticles, with remarkable physicochemical and mechanical properties, are FDA-approved biomaterials with potential biomedical aspects, like serum stability, biocompatibility, biodegradability, mucoadhesivity, non-immunogenicity, anti-inflammatory, desirable pharmacokinetics and pharmacodynamics, etc. CS-based materials are mentioned as ideal bioactive materials for fabricating nanofibrous scaffolds. Sustained and controlled drug release and in situ gelation are other potential advantages of these scaffolds. This review highlights the latest advances in the fabrication of innovative CS-based nanofibrous scaffolds as potential bioactive materials in regenerative medicine and drug delivery systems, with an outlook on their future applications.
如今，疾病的治疗存在着广泛的缺陷。这些局限性与当前模式在疾病的预后、诊断和治疗方面的低效能力有关。因此，开发新的方法来克服这些限制是非常必要的。壳聚糖（CS）纳米粒子具有显著的物理化学和机械性能，是经过美国食品和药物管理局批准的生物材料，具有潜在的生物医学方面的应用，如血清稳定性、生物相容性、可生物降解性、黏膜黏附性、非免疫原性、抗炎性、理想的药代动力学和药效学等。基于 CS 的材料被认为是用于制造纳米纤维支架的理想的生物活性材料。持续和控制药物释放和原位凝胶化是这些支架的其他潜在优势。本文综述了最新的关于壳聚糖基纳米纤维支架作为再生医学和药物输送系统中潜在的生物活性材料的创新性制造进展，并展望了它们未来的应用。
