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（Thunb.）Ser. 叶标准化水提物在脂肪生成过程中抑制作用的脂质组学评估。

Lipidomic Assessment of the Inhibitory Effect of Standardized Water Extract of (Thunb.) Ser. Leaves during Adipogenesis.

机构信息

Department of Integrative Biological Sciences and Industry, Sejong University, Seoul 05006, Republic of Korea.

Convergence Research Center for Natural Products, Sejong University, Seoul 05006, Republic of Korea.

出版信息

Nutrients. 2024 May 16;16(10):1508. doi: 10.3390/nu16101508.

DOI:10.3390/nu16101508
PMID:38794745
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11124303/
Abstract

Obesity is primarily exacerbated by excessive lipid accumulation during adipogenesis, with triacylglycerol (TG) as a major lipid marker. However, as the association between numerous lipid markers and various health conditions has recently been revealed, investigating the lipid metabolism in detail has become necessary. This study investigates the lipid metabolic effects of (Thunb.) Ser. hot water leaf extract (WHS) on adipogenesis using LC-MS-based lipidomics analysis of undifferentiated, differentiated, and WHS-treated differentiated 3T3-L1 cells. WHS treatment effectively suppressed the elevation of glycerolipids, including TG and DG, and prevented a molecular shift in fatty acyl composition towards long-chain unsaturated fatty acids. This shift also impacted glycerophospholipid metabolism. Additionally, WHS stabilized significant lipid markers such as the PC/PE and LPC/PE ratios, SM, and Cer, which are associated with obesity and related comorbidities. This study suggests that WHS could reduce obesity-related risk factors by regulating lipid markers during adipogenesis. This study is the first to assess the underlying lipidomic mechanisms of the adipogenesis-inhibitory effect of WHS, highlighting its potential in developing natural products for treating obesity and related conditions. Our study provides a new strategy for the development of natural products for the treatment of obesity and related diseases.

摘要

肥胖主要是由脂肪生成过程中脂质过度积累引起的，三酰甘油 (TG) 是主要的脂质标志物。然而，由于最近揭示了许多脂质标志物与各种健康状况之间的关联，因此有必要详细研究脂质代谢。本研究使用 LC-MS 基于脂质组学分析未分化、分化和 WHS 处理分化的 3T3-L1 细胞，研究了 （Thunb.） Ser 的脂质代谢效应。热水叶提取物 (WHS) 在脂肪生成中的作用。WHS 处理可有效抑制甘油脂质（包括 TG 和 DG）的升高，并防止脂肪酸组成向长链不饱和脂肪酸的分子转移。这种转变也影响了甘油磷脂代谢。此外，WHS 稳定了与肥胖和相关合并症相关的重要脂质标志物，如 PC/PE 和 LPC/PE 比、SM 和 Cer。本研究表明，WHS 通过调节脂肪生成过程中的脂质标志物，可能降低肥胖相关的危险因素。这项研究首次评估了 WHS 抑制脂肪生成的潜在脂质组学机制，突出了其在开发用于治疗肥胖和相关疾病的天然产物方面的潜力。我们的研究为治疗肥胖和相关疾病的天然产物的开发提供了一种新策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a4c/11124303/965aed2dd829/nutrients-16-01508-g007.jpg
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