Department of Orthopedics, The 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China.
Queen Mary School, Jiangxi Medical College, Nanchang University, Nanchang 330031, China.
Nutrients. 2024 May 16;16(10):1505. doi: 10.3390/nu16101505.
The high prevalence of constipation after fracture surgery brings intolerable discomfort to patients on the one hand, and affects post-surgery nutrient absorption on the other hand, resulting in poor prognosis. Given the acknowledged probiotic properties of , 100 fracture patients with post-surgery constipation were centrally enrolled and administered orally with JYLR-127 to assess the efficacy of probiotic-adjuvant therapy in alleviating post-fracture constipation symptoms. The results showed that JYLR-127 improved fecal properties, promoted gastrointestinal recovery, and relieved constipation symptoms, which were mainly achieved by elevating Firmicutes ( < 0.01) and descending Bacteroidetes ( < 0.001), hence remodeling the disrupted intestinal microecology. In addition, blood routine presented a decrease in C-reactive protein levels ( < 0.05) and an increase in platelet counts ( < 0.05) after probiotic supplementation, prompting the feasibility of JYLR-127 in anti-inflammation, anti-infection and hemorrhagic tendency prevention after fracture surgery. Our study to apply probiotics in ameliorating constipation after fracture surgery is expected to bless the bothered patients, and provide broader application scenarios for preparations.
骨折手术后便秘的高发率一方面给患者带来难以忍受的不适，另一方面影响术后营养吸收，导致预后不良。鉴于 被公认为益生菌，我们中心招募了 100 名骨折术后便秘患者，口服 JYLR-127，评估益生菌辅助治疗缓解骨折后便秘症状的疗效。结果表明，JYLR-127 改善了粪便特性，促进了胃肠道恢复，缓解了便秘症状，这主要是通过提高厚壁菌门（<0.01）和降低拟杆菌门（<0.001）来实现的，从而重塑了紊乱的肠道微生态。此外，益生菌补充后血常规表现为 C 反应蛋白水平下降（<0.05）和血小板计数增加（<0.05），提示 JYLR-127 在后骨折手术中具有抗炎、抗感染和预防出血倾向的可行性。我们应用益生菌改善骨折后便秘的研究有望造福于受困扰的患者，并为 制剂提供更广阔的应用场景。
