Department of General, Minimally Invasive and Elderly Surgery, Collegium Medicum, University of Warmia and Mazury, 10-045 Olsztyn, Poland.
Probios Ltd., 10-683 Olsztyn, Poland.
Nutrients. 2024 Oct 15;16(20):3498. doi: 10.3390/nu16203498.
Sleeve gastrectomy (SG) has become the predominant bariatric surgery, leading to significant weight loss and reductions in obesity-related complications. However, postoperative gastrointestinal symptoms such as constipation and bloating are common. This study aims to evaluate the impact of probiotic supplementation on postoperative gastrointestinal symptoms in patients undergoing SG. The secondary aim is to analyze laboratory and stool test results.
This prospective, placebo-controlled study included patients undergoing SG at a single center. Participants were adults without specific gastrointestinal diseases. They were randomly assigned to either the Probiotics or Controls group. Gastrointestinal symptoms and laboratory and stool tests were assessed before surgery and one month after.
Thirty-one patients participated, with 15 in the Probiotics group and 16 in the Controls group. Probiotic supplementation significantly increased the number of stools per week ( = 0.027) and reduced constipation incidence ( = 0.002). Patients in the Probiotics group reported easier defecation and greater bowel movement completeness ( = 0.015, = 0.004). No significant differences in weight loss or laboratory tests were observed between the groups. Stool microbiota analysis showed a return to normal levels of , , and in the Probiotics group and an increase in the Controls group.
Probiotic supplementation after SG significantly reduces constipation without adverse effects. These findings suggest that incorporating probiotics into postoperative care protocols can enhance patient comfort and recovery.
袖状胃切除术（SG）已成为主要的减重手术，可显著减轻体重并降低肥胖相关并发症的风险。然而，术后胃肠道症状如便秘和腹胀较为常见。本研究旨在评估益生菌补充对 SG 术后胃肠道症状的影响。次要目的是分析实验室和粪便检测结果。
这是一项单中心前瞻性、安慰剂对照研究，纳入了接受 SG 的患者。参与者为无特定胃肠道疾病的成年人。他们被随机分配到益生菌组或对照组。在手术前和术后一个月评估胃肠道症状、实验室和粪便检测结果。
共有 31 名患者参与，其中益生菌组 15 例，对照组 16 例。益生菌补充显著增加了每周排便次数（ = 0.027），降低了便秘发生率（ = 0.002）。益生菌组患者报告排便更轻松，大便更完整（ = 0.015， = 0.004）。两组间体重减轻或实验室检查无显著差异。粪便微生物组分析显示，益生菌组的 、 、 水平恢复正常，而对照组的水平升高。
SG 术后补充益生菌可显著减少便秘，无不良反应。这些发现表明，将益生菌纳入术后护理方案可以提高患者舒适度和恢复速度。
