Postgraduate Program in Dentistry, School of Dentistry University of Pernambuco, R. Arnóbio Marques, 310 50100-130, Recife, Pernambuco, Brazil
Med Oral Patol Oral Cir Bucal. 2024 Jul 1;29(4):e476-e482. doi: 10.4317/medoral.26454.
The lips are the transition zone between the facial skin and the oral mucosa and are the site of alterations related to a broad spectrum of etiologies. Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are the most prevalent neoplasms affecting lips. This study evaluated the demographic and clinicopathological features of the SCC and BCC in the lip.
A retrospective cross-sectional descriptive study (1994-2019) was carried out. Demographic and clinicopathologic data were collected from a hospital's dermatological service and an oncologic hospital. The data were submitted to descriptive analysis and Pearson's chi-square and Fisher's exact tests (p ≤ 0.05).
417 medical records were analyzed, of which 323 corresponded to SCC (77.5%) and 94 to BCC (22.5%). SCC showed more frequency in males (58.8%) and BCC in females (54.3%). The lower lip was significantly affected in male patients (p < 0.0001) and by both neoplasms (70.6% and 56.4%, respectively; p = 0.014). SCC and BCC were mainly treated with surgery (88.3% and 93.2%, respectively). Surgical margin was frequently negative in SCC and BCC (87%; 72.3%, respectively), and no recurrence was observed in 79.9% of SCC and 69.1% of BCC cases.
SCC was more frequent in male patients, while BCC showed more frequency in female patients. Both neoplasms mainly affect the lower lip. Understanding the epidemiological profile of these lesions in the lip, as well as their etiology and clinical features, is fundamental for appropriate clinical conduct and the creation and/or amplification of preventive measures.
嘴唇是面部皮肤和口腔黏膜的过渡区，是与广泛病因相关的改变部位。鳞状细胞癌（SCC）和基底细胞癌（BCC）是最常见的影响嘴唇的肿瘤。本研究评估了嘴唇 SCC 和 BCC 的人口统计学和临床病理特征。
进行了回顾性横断面描述性研究（1994-2019 年）。从医院皮肤科服务和肿瘤医院收集人口统计学和临床病理数据。数据进行描述性分析和 Pearson 卡方和 Fisher 精确检验（p≤0.05）。
分析了 417 份病历，其中 323 份为 SCC（77.5%），94 份为 BCC（22.5%）。SCC 男性发病率较高（58.8%），BCC 女性发病率较高（54.3%）。下嘴唇在男性患者中受影响更明显（p<0.0001），且两种肿瘤均受影响（分别为 70.6%和 56.4%；p=0.014）。SCC 和 BCC 主要采用手术治疗（分别为 88.3%和 93.2%）。SCC 和 BCC 的手术切缘常为阴性（分别为 87%和 72.3%），SCC 无复发率为 79.9%，BCC 无复发率为 69.1%。
SCC 在男性患者中更为常见，而 BCC 在女性患者中更为常见。两种肿瘤主要影响下唇。了解嘴唇这些病变的流行病学特征、病因和临床特征，对于适当的临床治疗以及预防措施的制定和/或加强至关重要。
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