Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Departamento de Clínica, Patologia e Cirurgias Odontológicas, Faculdade de Odontologia, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos, 6627, sala 3202 D. Pampulha, Belo Horizonte, MG, CEP 31270-901, Brazil.
Head Neck Pathol. 2020 Dec;14(4):899-908. doi: 10.1007/s12105-020-01142-2. Epub 2020 Feb 19.
Data on the occurrence and clinicopathological characteristics of actinic cheilitis (AC) and lip squamous cell carcinoma (LSCC) are well studied; however, they are based on studies limited to a single centre. Herein, we described the frequency of AC and LSCC submitted to microscopic examination from representative geographic regions of Brazil. A retrospective multicentre study was performed on biopsies obtained from 1953 to 2018 at 10 Brazilian oral and maxillofacial pathology centres. A total of 198,709 biopsy specimens were surveyed. Sociodemographic data and clinicopathologic characteristics were analysed. A total of 2017 cases of ACs (1.0%) and 850 cases of LSCCs (0.4%) were recorded. A strong fair-skinned (> 87%) male (> 70%) predilection was observed in both conditions. The mean age was 54.8 ± 18.7 for individuals with AC and 57.8 ± 19.0 for individuals with LSCC. The most commonly affected site was the lower lip (> 90%). This is a large multicentre study of AC and LSCC from Brazil. The frequency and clinicopathological features of AC and LSCC were similar to those described worldwide. This study provides robust and representative epidemiological data of these conditions for the scientific community.
光化性唇炎（AC）和唇鳞状细胞癌（LSCC）的发病和临床病理特征已有大量研究；然而，这些研究基于仅局限于单一中心的研究。在此，我们描述了巴西具有代表性地理区域提交显微镜检查的 AC 和 LSCC 的频率。对 10 个巴西口腔颌面病理学中心 1953 年至 2018 年获得的活检进行了回顾性多中心研究。共调查了 198709 例活检标本。分析了社会人口统计学数据和临床病理特征。共记录了 2017 例 AC（1.0%）和 850 例 LSCC（0.4%）。两种情况下均观察到强白皙皮肤（>87%）的男性（>70%）偏好。AC 患者的平均年龄为 54.8±18.7，LSCC 患者为 57.8±19.0。最常受影响的部位是下唇（>90%）。这是一项针对巴西 AC 和 LSCC 的大型多中心研究。AC 和 LSCC 的频率和临床病理特征与全球描述的相似。该研究为科学界提供了这些疾病的可靠和代表性的流行病学数据。
