Alstead E M, Grime J S, Critchley M, Morris A I, Gilmore I T, Ware J
Nucl Med Commun. 1985 Nov;6(11):707-15. doi: 10.1097/00006231-198511000-00005.
Liver volume and parenchymal cell uptake of 123I-bromosulphthalein (BSP) has been assessed using the technique of single photon emission tomography (SPET). These results have been compared with a clinical scoring of disease severity and also with results for liver volume and tomographically assessed uptake of 99Tcm-sulphur colloid (SC). Comparisons of volume estimation, geometric mean (GM) uptake curves and a distribution index derived by a mapping technique with both radiopharmaceuticals, show that 123I-BSP tomography is feasible. A short acquisition time is required in order to obtain tomographic information before there is significant biliary excretion. There was a significant difference between the mean percentage uptake of 123I-BSP in the three groups of liver disease severity (P less than 0.002). This technique merits further evaluation in the study of the assessment of functional liver impairment.
利用单光子发射断层扫描（SPET）技术评估了肝脏体积以及123I-溴磺酞钠（BSP）的实质细胞摄取情况。已将这些结果与疾病严重程度的临床评分以及肝脏体积结果和断层扫描评估的99Tcm-硫胶体（SC）摄取情况进行了比较。对两种放射性药物的体积估计、几何平均（GM）摄取曲线以及通过映射技术得出的分布指数进行比较，结果表明123I-BSP断层扫描是可行的。为了在胆汁排泄显著之前获取断层扫描信息，需要较短的采集时间。三组肝脏疾病严重程度的123I-BSP平均摄取百分比之间存在显著差异（P<0.002）。该技术在功能性肝损伤评估研究中值得进一步评估。
