Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, India.
Department of Microbiology, Adamas University, Barasat, Kolkata 700126, India.
Drug Discov Today. 2024 Jul;29(7):104044. doi: 10.1016/j.drudis.2024.104044. Epub 2024 May 23.
The increase in diseases caused by RNA viruses, such as influenza, severe acute respiratory syndrome-coronavirus (SARS-CoV), Middle East respiratory syndrome (MERS), and Ebola, presents a growing global health challenge as well as the threat of zoonosis. Traditional antiviral treatments are often undermined by fast-mutating viruses, drug resistance, and newly emerging pathogens. Here, we explore proteolysis-targeting chimeras (PROTACs), a novel protein degradation machinery that has the potential to reshape the way in which RNA viral infections can be managed. PROTACs excel at specifically degrading pathogenic proteins, offering a targeted and efficient antiviral strategy. We also investigate the potential of exosome-based diagnostic technologies, which harness cell-derived nanovesicles for non-invasive sampling and early viral infection detection. Addressing the challenge of PROTAC delivery, we introduce a groundbreaking strategy utilizing exosomes to deliver PROTACs with improved precision and as a targeted delivery vehicle. Integrating these innovative strategies provides a novel approach to combat RNA zoonotic viral diseases, paving the way for a new era in antiviral therapy.
RNA 病毒引起的疾病不断增加，如流感、严重急性呼吸综合征冠状病毒（SARS-CoV）、中东呼吸综合征（MERS）和埃博拉病毒等，这些疾病对全球健康构成了日益严峻的挑战，也存在着人畜共患病的威胁。传统的抗病毒治疗方法往往因病毒快速突变、耐药性和新出现的病原体而受到影响。在这里，我们探讨了蛋白水解靶向嵌合体（PROTACs），这是一种新型的蛋白质降解机制，有可能改变 RNA 病毒感染的管理方式。PROTACs 在特异性降解致病蛋白方面表现出色，提供了一种靶向且高效的抗病毒策略。我们还研究了基于外泌体的诊断技术的潜力，该技术利用细胞衍生的纳米囊泡进行非侵入性采样和早期病毒感染检测。为了解决 PROTAC 传递的挑战，我们引入了一种开创性的策略，利用外泌体来提高 PROTAC 的传递精度，并作为靶向传递载体。整合这些创新策略为对抗 RNA 人畜共患病病毒疾病提供了一种新方法，为抗病毒治疗的新时代铺平了道路。
