Yang Qing, Wang Wei, Cheng Dezhou, Wang Yiling, Han Yukun, Huang Jinbai, Peng Xiaochun
Nuclear Medicine Department, The First Affiliated Hospital of Yangtze University, Jingzhou 434000, Hubei, China; Health Science Center of Yangtze University, Jingzhou 434023, Hubei, China.
Department of Rehabilitation Radiology, Beijing Rehabilitation Hospital, Capital Medical University, Beijing 100144, China.
Transl Oncol. 2024 Aug;46:102002. doi: 10.1016/j.tranon.2024.102002. Epub 2024 May 25.
Lung cancer is a highly prevalent malignancy with poor prognosis and rapid progression. It most frequently metastasizes to the bone, where it can pose a severe threat to the patient's survival. Once metastasized, the disease is often incurable and can result in severe complications such as hypercalcemia, bone pain, fractures, spinal cord compression, and subsequent paralysis. Exosomes are bilayer vesicle nanoparticles secreted by most of the extracellular vesicles, which can be found in almost all organisms and play an essential role in intercellular communication. Through their ability to regulate related bone cells, exosomes carry bioactive molecules, including proteins, lipids, and non-coding RNAs (ncRNAs), that can be extremely important in bone remodeling. Studies have been conducted on the role play by proteins, lncRNA, and microRNA-all ncRNAs-carried by exosomes in the bone metastases of lung cancer. In this review, the latest progress of the regulatory mechanism of ncRNAs carried by exosomes in lung cancer bone metastasis has been reviewed. The clinical use of exosomes as a promising biomarker, drug transporter, and therapeutic target was highlighted to offer a novel diagnostic and treatment approach for patients with lung cancer bone metastases.
肺癌是一种高度常见的恶性肿瘤，预后较差且进展迅速。它最常转移至骨骼，在那里会对患者的生存构成严重威胁。一旦发生转移，该疾病往往无法治愈，并可能导致严重并发症，如高钙血症、骨痛、骨折、脊髓压迫及随后的瘫痪。外泌体是大多数细胞外囊泡分泌的双层囊泡纳米颗粒，几乎在所有生物体中都能找到，并且在细胞间通讯中发挥着重要作用。外泌体通过调节相关骨细胞的能力，携带生物活性分子，包括蛋白质、脂质和非编码RNA（ncRNAs），这些分子在骨重塑过程中可能极其重要。针对外泌体携带的蛋白质、长链非编码RNA和微小RNA（均为ncRNAs）在肺癌骨转移中的作用已开展了多项研究。在本综述中，对外泌体携带的ncRNAs在肺癌骨转移中的调控机制的最新进展进行了综述。强调了外泌体作为一种有前景的生物标志物、药物转运体和治疗靶点的临床应用，为肺癌骨转移患者提供一种新的诊断和治疗方法。
