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一项评估动物非致命性狂犬病的研究。

A study to evaluate non-fatal rabies in animals.

作者信息

Botros B A, Lewis J C, Kerkor M

出版信息

J Trop Med Hyg. 1979 Jul;82(7):137-41.

PMID:387971
Abstract

Brains and salivary glands of stray dogs, cats and wild mammals were examined for latent rabies virus. Sera of these animals were tested for rabits neutralizing antibody. Dogs and rodents of the gerbil species were experimentally infected with rabies viruses tryping to produce nonfatal rabies. The following conclusions are made: 1. Naturally occurring nonfatal rabies infection evidenced by recovery of the virus was not present in the stray dogs examined and could not be produced experimentally. 2. Among wild gerbils showing no signs of disease, recovery of (latent) virus was possible but this condition could not be reproduced experimentally. However they could have been in the incubation stage. 3. Development of rabies neutralizing antibody did not occur naturally in wild rodents, but occurred in dogs. Antibody to rabies was detected in surviving gerbils after experimental infection. The antibody probably develops subsequent to sublinical nonfatal infection. 4. Non-fatal infection, indicated either by recovery of rabies virus or detection of neutralizing antibody, was not detected among the examined cats.

摘要

对流浪狗、猫和野生哺乳动物的大脑及唾液腺进行了潜伏狂犬病病毒检测。检测了这些动物的血清中的狂犬病中和抗体。用狂犬病病毒对沙鼠品种的狗和啮齿动物进行实验性感染,试图制造非致命性狂犬病。得出以下结论:1. 在检测的流浪狗中不存在由病毒复现证明的自然发生的非致命性狂犬病感染,且无法通过实验制造。2. 在无疾病迹象的野生沙鼠中,有可能复现(潜伏)病毒,但这种情况无法通过实验再现。不过它们可能处于潜伏期。3. 野生啮齿动物不会自然产生狂犬病中和抗体,但狗会。在实验感染后,在存活的沙鼠中检测到了狂犬病抗体。该抗体可能在亚临床非致命感染后产生。4. 在检测的猫中未检测到由狂犬病病毒复现或中和抗体检测表明的非致命感染。

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