McCorquodale D J, Shaw A R, Moody E E, Hull R A, Morgan A F
J Virol. 1979 Jul;31(1):31-41. doi: 10.1128/JVI.31.1.31-41.1979.
Infection of Escherichia coli harboring ColIb+ plasmids with bacteriophage BF23+ is abortive and resulted in changes of membrane permeability as measured by efflux of nucleotides and K+. A single pre-early gene product of BF23+ was necessary and sufficient to elicit the abortive response. Appropriate mutations in this pre-early gene allowed a productive infection in ColIb+ cells. Appropriate mutations in the ColIb plasmid also allowed a productive infection with BF23+. A comparison of changes occurring during abortive infection and during killing of sensitive cells by external colicin Ib or Ia, together with certain genetic data, has led to the conclusion that membrane changes accompanying the two phenomena are the result of a common mechanism, namely, the interaction of free colicin with the cytoplasmic membrane.
携带ColIb + 质粒的大肠杆菌被噬菌体BF23 + 感染是流产性的，并且会导致膜通透性的改变，这可通过核苷酸和钾离子的外流来测定。BF23 + 的单个早期前体基因产物引发流产性反应既必要又充分。该早期前体基因中的适当突变可使ColIb + 细胞发生有效感染。ColIb质粒中的适当突变也可使BF23 + 发生有效感染。对流产性感染期间以及外部大肠菌素Ib或Ia杀死敏感细胞期间发生的变化进行比较，再结合某些遗传数据，得出的结论是，伴随这两种现象的膜变化是一种共同机制的结果，即游离大肠菌素与细胞质膜的相互作用。
