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院前麻醉的标准操作程序及其对死亡率的影响——一项观察性研究。

A standard operating procedure for prehospital anaesthesia and its effect on mortality-An observational study.

机构信息

Emergency Medicine and Services, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Emergency Medical Services, Turku University Hospital, University of Turku, Turku, Finland.

出版信息

Acta Anaesthesiol Scand. 2024 Sep;68(8):1068-1075. doi: 10.1111/aas.14459. Epub 2024 May 26.

Abstract

BACKGROUND

Prehospital anaesthesia is a complex intervention performed for critically ill patients. To minimise complications, a standard operating procedure (SOP) outlining the process is considered valuable. We investigated the implementation of an SOP for prehospital anaesthesia in helicopter emergency medical services (HEMS).

METHODS

We performed a retrospective observational study of patients receiving prehospital anaesthesia by Finnish HEMS from January 2012 to August 2019. The intervention studied was the implementation of an SOP at two of the five bases during 2015-2016. Patients were stratified according to whether they were anaesthetised before, during or after implementation and the primary outcomes were 1- and 30-day mortality. Secondary outcomes included anaesthesia quality indicators. Confounding factors was assessed via logistic regression.

RESULTS

A total of 3902 tracheal intubations were performed without an SOP, 430 during implementation and 1525 after implementation. The SOP had a significant effect on 1-day mortality during implementation with an odds ratio (OR) of 0.56, 95% confidence interval (95% CI) 0.37-0.81 and a further trend towards benefit after implementation (OR 0.84, 95% CI 0.68-1.04), but no difference in 30-day mortality (OR after implementation 1.10, 95% CI 0.92-1.30). Implementation of an SOP improved first-pass success rate from 87.3% to 96.5%, p < 0.001.

CONCLUSION

Implementation of an SOP for prehospital anaesthesia was associated with a trend towards lower 1-day mortality and an improved first-pass success but did not affect 30-day mortality. Despite this, we advocate prehospital systems to consider implementation of a prehospital anaesthesia SOP as immediate performance markers improved significantly.

摘要

背景

院前麻醉是对危重病患者进行的一项复杂干预措施。为了最大限度地减少并发症,制定了一份标准操作程序(SOP)来概述这一过程,被认为是有价值的。我们调查了在直升机紧急医疗服务(HEMS)中实施院前麻醉 SOP 的情况。

方法

我们对 2012 年 1 月至 2019 年 8 月期间芬兰 HEMS 为患者进行院前麻醉的情况进行了回顾性观察研究。所研究的干预措施是在 2015 年至 2016 年期间在五个基地中的两个基地实施 SOP。根据患者在实施前、实施期间和实施后进行麻醉的情况进行分层,主要结局为 1 天和 30 天死亡率。次要结局包括麻醉质量指标。通过逻辑回归评估混杂因素。

结果

在没有 SOP 的情况下共进行了 3902 次气管插管,实施期间进行了 430 次,实施后进行了 1525 次。SOP 的实施对 1 天死亡率有显著影响,优势比(OR)为 0.56,95%置信区间(95%CI)为 0.37-0.81,实施后仍有获益趋势(OR 为 0.84,95%CI 为 0.68-1.04),但 30 天死亡率无差异(实施后 OR 为 1.10,95%CI 为 0.92-1.30)。实施 SOP 后,首次通过成功率从 87.3%提高到 96.5%,p<0.001。

结论

实施院前麻醉 SOP 与 1 天死亡率降低和首次通过成功率提高的趋势相关,但不影响 30 天死亡率。尽管如此,我们仍主张院前系统考虑实施院前麻醉 SOP,因为即时绩效指标显著改善。

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