银纳米粒子的绿色合成及其对牙龈卟啉单胞菌生物膜形成的影响评价。
Green synthesis of silver nanoparticles and evaluation of their effects on the Porphyromonas gingivalis bacterial biofilm formation.
机构信息
Department of Periodontics, Faculty of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.
Dental Implant Research Center, Faculty of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.
出版信息
Clin Exp Dent Res. 2024 Jun;10(3):e887. doi: 10.1002/cre2.887.
OBJECTIVE
This study aimed to evaluate the impact of silver nanoparticles (AgNPs) synthesized from propolis on the formation of Porphyromonas gingivalis biofilms.
MATERIAL AND METHODS
AgNPs were synthesized from propolis, and their inhibitory effect on P. gingivalis biofilm formation was assessed. Different concentrations of AgNPs (0.1%, 0.3%, and 0.5%) were tested to determine the dose-dependent antibacterial activity.
RESULTS
The results of this study indicated that AgNPs exhibited an inhibitory effect on P. gingivalis biofilm formation. The antibacterial activity of AgNPs was dose-dependent, with concentrations of 0.1%, 0.3%, and 0.5% showing effectiveness. Notably, the concentration of 0.5% demonstrated the most significant anti-biofilm formation activity.
CONCLUSION
The results of this study suggest that AgNPs synthesized from propolis have potential as an effective option for enhancing periodontal treatment outcomes. The inhibitory effect of AgNPs on P. gingivalis biofilm formation highlights their potential as alternative antimicrobial agents in the management of periodontal diseases.
目的
本研究旨在评估从蜂胶中合成的银纳米粒子（AgNPs）对牙龈卟啉单胞菌生物膜形成的影响。
材料和方法
从蜂胶中合成 AgNPs，并评估其对牙龈卟啉单胞菌生物膜形成的抑制作用。测试了不同浓度（0.1%、0.3%和 0.5%）的 AgNPs，以确定其剂量依赖性的抗菌活性。
结果
本研究结果表明，AgNPs 对牙龈卟啉单胞菌生物膜形成具有抑制作用。AgNPs 的抗菌活性呈剂量依赖性，浓度为 0.1%、0.3%和 0.5%具有有效性。值得注意的是，浓度为 0.5%表现出最显著的抗生物膜形成活性。
结论
本研究结果表明，从蜂胶中合成的 AgNPs 具有增强牙周治疗效果的潜力。AgNPs 对牙龈卟啉单胞菌生物膜形成的抑制作用突出了其作为牙周病管理中替代抗菌剂的潜力。
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