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Front Immunol. 2024 May 10;15:1388667. doi: 10.3389/fimmu.2024.1388667. eCollection 2024.
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本文引用的文献

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Cerebellar ataxia as the initial symptom with lesions involving the cerebellum in patient with anti-NMDAR encephalitis: A rare case report and literature review.以小脑性共济失调为首发症状且小脑受累的抗NMDAR脑炎患者：1例罕见病例报告及文献复习
J Neuroimmunol. 2020 Sep 15;346:577293. doi: 10.1016/j.jneuroim.2020.577293. Epub 2020 Jun 17.
2
Cerebellar ataxia as a presenting symptom in a patient with anti-NMDA receptor encephalitis.小脑共济失调作为抗N-甲基-D-天冬氨酸受体脑炎患者的首发症状。
Neurol Neuroimmunol Neuroinflamm. 2019 Jun 4;6(4):e579. doi: 10.1212/NXI.0000000000000579. eCollection 2019 Jul.
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Recent advances in understanding the mechanisms of cerebellar granule cell development and function and their contribution to behavior.在理解小脑颗粒细胞发育和功能机制及其对行为的贡献方面的最新进展。
F1000Res. 2018 Jul 26;7. doi: 10.12688/f1000research.15021.1. eCollection 2018.
4
Sensorimotor Representations in Cerebellar Granule Cells in Larval Zebrafish Are Dense, Spatially Organized, and Non-temporally Patterned.幼虫斑马鱼小脑颗粒细胞中的感觉运动表征丰富、空间组织有序且非时间模式化。
Curr Biol. 2017 May 8;27(9):1288-1302. doi: 10.1016/j.cub.2017.03.029. Epub 2017 Apr 20.
5
Cerebellar granule cells acquire a widespread predictive feedback signal during motor learning.小脑颗粒细胞在运动学习过程中获得广泛的预测性反馈信号。
Nat Neurosci. 2017 May;20(5):727-734. doi: 10.1038/nn.4531. Epub 2017 Mar 20.
6
Association of Progressive Cerebellar Atrophy With Long-term Outcome in Patients With Anti-N-Methyl-d-Aspartate Receptor Encephalitis.抗 N-甲基-D-天冬氨酸受体脑炎患者进行性小脑萎缩与长期预后的关系。
JAMA Neurol. 2016 Jun 1;73(6):706-13. doi: 10.1001/jamaneurol.2016.0232.
7
Anti-NMDAR encephalitis: demonstration of neuroinflammation and the effect of immunotherapy.抗N-甲基-D-天冬氨酸受体（NMDAR）脑炎：神经炎症的证实及免疫治疗的效果
Neurology. 2015 Feb 24;84(8):859. doi: 10.1212/WNL.0000000000001278.
8
A novel treatment-responsive encephalitis with frequent opsoclonus and teratoma.一种新型治疗反应性脑炎，常伴有眼震和畸胎瘤。
Ann Neurol. 2014 Mar;75(3):435-41. doi: 10.1002/ana.23917. Epub 2013 Sep 10.
9
Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study.抗 NMDA 受体脑炎患者的长期预后的治疗和预后因素：一项观察性队列研究。
Lancet Neurol. 2013 Feb;12(2):157-65. doi: 10.1016/S1474-4422(12)70310-1. Epub 2013 Jan 3.
10
Progressive encephalomyelitis with rigidity and myoclonus: glycine and NMDA receptor antibodies.进行性脑脊髓炎伴僵硬和肌阵挛：甘氨酸和 NMDA 受体抗体。
Neurology. 2011 Aug 2;77(5):439-43. doi: 10.1212/WNL.0b013e318227b176. Epub 2011 Jul 20.

病例报告：抗 N-甲基-D-天冬氨酸受体脑炎患者孤立性脑干-小脑症状。

Case report: Isolated brainstem-cerebellar symptoms in a patient with anti-NMDA receptor encephalitis.

机构信息

Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

出版信息

Front Immunol. 2024 May 10;15:1388667. doi: 10.3389/fimmu.2024.1388667. eCollection 2024.

DOI:10.3389/fimmu.2024.1388667
PMID:38799430
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11116719/
Abstract

Cerebellar ataxia is an uncommon and atypical manifestation of anti--methyl-D-aspartate receptor (NMDAR) encephalitis, often accompanied by seizures, psychiatric symptoms, and cognitive deficits. Previous cases of isolated brainstem-cerebellar symptoms in patients with anti-NMDAR encephalitis have not been documented. This report presents a case of anti-NMDAR encephalitis in which the patient exhibited cerebellar ataxia, nystagmus, diplopia, positive bilateral pathological signs, and hemiparesthesia with no other accompanying symptoms or signs. The presence of positive CSF anti-NMDAR antibodies further supports the diagnosis. Other autoantibodies were excluded through the use of cell-based assays. Immunotherapy was subsequently administered, leading to a gradual recovery of the patient.

摘要

小脑性共济失调是抗 N-甲基-D-天冬氨酸受体（NMDAR）脑炎的一种不常见且非典型表现，常伴有癫痫发作、精神症状和认知缺陷。以前没有记录到抗 NMDAR 脑炎患者孤立的脑干-小脑症状的病例。本报告介绍了一例抗 NMDAR 脑炎患者，该患者表现为小脑共济失调、眼球震颤、复视、双侧病理征阳性和半身感觉障碍，无其他伴随症状或体征。脑脊液抗 NMDAR 抗体阳性进一步支持诊断。通过使用基于细胞的检测排除了其他自身抗体。随后进行了免疫治疗，患者逐渐康复。