Huet Karl, White Michael, Griffon Anne-Fleur, Bloch Emma, Magnat Elodie, Baudemont Gaelle, Inizan Catherine, Domingue Mena Pascale, Dupont-Rouzeyrol Myrielle
Institut Pasteur of New Caledonia, URE Dengue and Arboviruses, Pasteur Network, Noumea, Noumea, New Caledonia.
Infectious Disease Epidemiology and Analytics G5 Unit, Department of Global Health, Institut Pasteur, Université Paris Cité, Paris, France.
IJID Reg. 2024 May 1;11:100373. doi: 10.1016/j.ijregi.2024.100373. eCollection 2024 Jun.
This study aimed to determine the seroprevalence of immunoglobulin G antibodies targeting SARS-CoV-2 and other human coronaviruses after the first circulation of SARS-CoV-2 in New Caledonia, Pacific region.
Blood samples were collected to detect the presence of SARS-CoV-2 immunoglobulin G antibodies. The sampling took place between July 2021 and July 2022 but was interrupted after the first circulation of SARS-CoV-2 (September 2021-March 2022) in New Caledonia. Data on ethnicity, age, gender, main residence, and anteriority of COVID-19 and vaccination were collected and analyzed.
A total of 747 participants, representative of New Caledonia's adult population, were included in the study. We found that 81% of the population had antibody responses to SARS-CoV-2 at the end of July 2022. The vaccination rate was 75%, whereas infections had affected 40% of the population. Individuals aged >45 years were significantly more vaccinated than those aged 18-44 years (80%, 95% confidence interval 74-84%). Oceanians were the most infected (50%, 95% confidence interval 42-57%).
In New Caledonia, we show a high immunity rate (81%) after the first waves of SARS-CoV-2 circulation and the vaccination campaign. The analyses showed spatial heterogeneities in the infection rate across the territory and revealed that Oceanians were the most infected. Our study also highlighted high exposure of New Caledonia's population to other human coronaviruses.
本研究旨在确定在太平洋地区新喀里多尼亚首次出现新冠病毒传播后，针对新冠病毒和其他人类冠状病毒的免疫球蛋白G抗体的血清流行率。
采集血样以检测新冠病毒免疫球蛋白G抗体的存在。采样于2021年7月至2022年7月期间进行，但在新喀里多尼亚首次出现新冠病毒传播（2021年9月至2022年3月）后中断。收集并分析了有关种族、年龄、性别、主要居住地以及新冠病毒感染和疫苗接种的先后顺序的数据。
共有747名代表新喀里多尼亚成年人口的参与者纳入本研究。我们发现，到2022年7月底，81%的人口对新冠病毒有抗体反应。疫苗接种率为75%，而感染影响了40%的人口。45岁以上的人接种疫苗的比例明显高于18 - 44岁的人（80%，95%置信区间74 - 84%）。大洋洲人感染率最高（50%，95%置信区间42 - 57%）。
在新喀里多尼亚，我们发现在新冠病毒首次传播浪潮和疫苗接种运动之后，免疫率很高（81%）。分析显示该地区各地的感染率存在空间异质性，并表明大洋洲人感染率最高。我们的研究还突出了新喀里多尼亚人口对其他人类冠状病毒的高暴露率。
