Jerah Ahmed Ali, Farasani Abdullah, Abu-Tawil Hisham I, Kuriri Hadi, Kuriri Anwar, Alkhayrat Mansour, Kariri Kholood, Kariri Sami Ali, Abdelwahab Siddig I
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, Jazan, SAU.
Biomedical Research Unit, Medical Research Center, Jazan University, Jazan, SAU.
Cureus. 2024 Apr 24;16(4):e58889. doi: 10.7759/cureus.58889. eCollection 2024 Apr.
Coronavirus disease 2019 (COVID-19) has had a significant impact on global health and healthcare systems. This retrospective study aimed to assess the association between biochemical parameters and outcomes in COVID-19 patients in Jazan, Saudi Arabia.
After establishing the inclusion criteria and obtaining ethical approval, data from 156 reverse transcriptase-polymerase chain reaction (RT-PCR)-confirmed COVID-19 patients were collected from electronic medical records from a general hospital in Samtah, Jazan, from April 2020 to October 2021. The collected data included patient demographics and liver, kidney, heart, and electrolyte function marker levels. Descriptive, inferential, and principal component analyses were conducted.
Survival rates varied according to age and body mass index (BMI). Statistical analysis demonstrated that the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), sodium (Na), potassium (K), blood urea nitrogen (BUN), creatinine (Cr), creatine kinase (CK), CK myocardial band (MB), and lactate dehydrogenase (LDH) were significantly higher (P < 0.05) than the reference values, as assessed using the one-sample t-test. Principal component analysis (PCA) also revealed an underlying pattern in the variation of these biochemical markers. These findings suggest that certain biochemical parameters may serve as useful indicators for monitoring the condition of COVID-19 patients.
This retrospective study in Jazan, Saudi Arabia highlights the association between biochemical parameters and outcomes in COVID-19 patients. Elevated levels of markers of liver, kidney, heart, and electrolyte function suggest organ damage and dysregulation. The pattern identified through PCA provides insights into disease severity. Monitoring these parameters may serve as valuable indicators for assessing COVID-19 patients. Further research is needed to validate these findings, explore their potential for personalized treatment strategies, and improve patient outcomes during the ongoing pandemic.
2019冠状病毒病（COVID-19）对全球健康和医疗系统产生了重大影响。这项回顾性研究旨在评估沙特阿拉伯吉赞地区COVID-19患者生化参数与预后之间的关联。
在确定纳入标准并获得伦理批准后，从2020年4月至2021年10月期间吉赞省萨姆塔赫市一家综合医院的电子病历中收集了156例经逆转录聚合酶链反应（RT-PCR）确诊的COVID-19患者的数据。收集的数据包括患者人口统计学信息以及肝脏、肾脏、心脏和电解质功能标志物水平。进行了描述性、推断性和主成分分析。
生存率因年龄和体重指数（BMI）而异。统计分析表明，使用单样本t检验评估时，天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、碱性磷酸酶（ALP）、钠（Na）、钾（K）、血尿素氮（BUN）、肌酐（Cr）、肌酸激酶（CK）、CK心肌同工酶（MB）和乳酸脱氢酶（LDH）水平显著高于参考值（P<0.05）。主成分分析（PCA）还揭示了这些生化标志物变化的潜在模式。这些发现表明，某些生化参数可能作为监测COVID-19患者病情的有用指标。
沙特阿拉伯吉赞地区的这项回顾性研究突出了COVID-19患者生化参数与预后之间的关联。肝脏、肾脏、心脏和电解质功能标志物水平升高表明器官损伤和功能失调。通过PCA确定的模式为疾病严重程度提供了见解。监测这些参数可能作为评估COVID-19患者的有价值指标。需要进一步研究来验证这些发现，探索其在个性化治疗策略中的潜力，并在当前大流行期间改善患者预后。
