Pattnaik Bodhiswata, Mohanty Sweta, Das Surya Narayan, Rath Rachna, Bhatta Archana, Mishra Sourav
Department of Oral Pathology and Microbiology, SCB Government Dental College and Hospital, Cuttack, Odisha, India.
Department of Oral Pathology and Microbiology, Institute of Dental Sciences, Siksha 'O' Anusandhan, Deemed to be University, Bhubaneswar, Odisha, India.
J Oral Maxillofac Pathol. 2024 Jan-Mar;28(1):49-55. doi: 10.4103/jomfp.jomfp_215_23. Epub 2024 Apr 15.
Ameloblastoma is one of the major odontogenic neoplasms with an invasive and recurrence potential. Its tumourigenesis and proliferative capacity can be attributed to the activation or inactivation of certain molecular signalling pathways. Hippo signalling pathway is known to regulate diverse physiological processes related to mitosis and organ growth and is an emerging tumour suppressor pathway, the dysfunction of which is implicated in various diseases including cancers. Yes-associated protein1 (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are the downstream effectors in the Hippo cascade, which on nuclear activation leads to cellular proliferation in various tumours.
The current study was undertaken to evaluate the expression of YAP in various histopathological variants of ameloblastoma and unicystic ameloblastoma.
Fifty formalin-fixed paraffin-embedded tissue samples of histopathologically diagnosed cases of ameloblastoma, and 10 histopathologically diagnosed cases of unicystic ameloblastoma were obtained from the departmental archives to evaluate the immunohistochemical expression of YAP both manually and by software analysis.
More than 90% of cases of conventional ameloblastoma and unicystic ameloblastoma elicited positive expression of YAP. No statistical difference was found among different histopathological variants of conventional ameloblastoma. Significant difference between the means of all four quantitative score groups was observed.
In view of the modulating effect of YAP in tumourigenesis and its higher expression in ameloblastoma, further exploration of this molecule appears to be a promising area of research.
成釉细胞瘤是主要的牙源性肿瘤之一，具有侵袭性和复发潜能。其肿瘤发生和增殖能力可归因于某些分子信号通路的激活或失活。已知Hippo信号通路调节与有丝分裂和器官生长相关的多种生理过程，是一条新兴的肿瘤抑制通路，其功能障碍与包括癌症在内的各种疾病有关。Yes相关蛋白1（YAP）和含PDZ结合基序的转录共激活因子（TAZ）是Hippo级联反应的下游效应分子，它们在细胞核内激活后会导致各种肿瘤中的细胞增殖。
本研究旨在评估YAP在成釉细胞瘤和单囊性成釉细胞瘤的各种组织病理学变体中的表达。
从科室档案中获取50例经组织病理学诊断的成釉细胞瘤福尔马林固定石蜡包埋组织样本，以及10例经组织病理学诊断的单囊性成釉细胞瘤样本，通过手动和软件分析评估YAP的免疫组化表达。
超过90%的传统成釉细胞瘤和单囊性成釉细胞瘤病例YAP呈阳性表达。传统成釉细胞瘤的不同组织病理学变体之间未发现统计学差异。观察到所有四个定量评分组的均值之间存在显著差异。
鉴于YAP在肿瘤发生中的调节作用及其在成釉细胞瘤中的高表达，对该分子的进一步探索似乎是一个有前景的研究领域。
