Kung H F, Billings J, Farrell E, Blau M
Department of Nuclear Medicine, SUNY, Buffalo.
Nucl Med Commun. 1985 Feb;6(2):75-81.
Anaesthetics are shown to affect the brain uptake of two pH-shift brain imaging agents, di-B-(morpholinoethyl)-selenide and N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine significantly. This is probably due to changing regional cerebral blood flow. The present study reaffirms previous observations that small disturbances such as stress and type of anaesthesia will significantly alter the regional cerebral blood flow and, as a consequence, brain uptake in rats. This is an important factor to consider when measuring or comparing brain uptake data.
麻醉剂被证明会显著影响两种pH值变化脑成像剂——二 -β-（吗啉代乙基）-硒化物和N，N，N'-三甲基-N'-（2-羟基-3-甲基-5-碘苄基）-1，3-丙二胺的脑摄取。这可能是由于局部脑血流的改变。本研究再次证实了先前的观察结果，即诸如应激和麻醉类型等小干扰会显著改变大鼠的局部脑血流，进而影响脑摄取。这是在测量或比较脑摄取数据时需要考虑的一个重要因素。
