State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Department of Periodontics, University of lowa College of Dentistry, lowa City, IA, USA.
Clin Oral Investig. 2024 May 27;28(6):341. doi: 10.1007/s00784-024-05732-0.
The purpose of this systemic review and meta-analysis was to explore the association between halitosis and periodontitis in observational studies.
A systematic search covered PubMed, Web of Science, Embase, Scopus, and Cochrane Library until August 18, 2023. Nine observational studies (585 cases, 1591 controls) were analyzed using Stata 17, with odds ratios (ORs) and 95% confidence intervals (CIs). Subgroup analyses considered halitosis assessment methods.
The review found a positive association between halitosis and periodontitis. Significant differences were observed with organoleptic test (OR = 4.05, 95% CI: 1.76, 9.30, p < 0.01) and volatile sulfur compound readings (OR = 4.52, 95% CI: 1.89, 10.83, p < 0.01).
A positive association was observed between halitosis and periodontitis, supported by significant differences in both organoleptic and volatile sulfur compound readings. However, conclusive findings are limited by statistical heterogeneity, emphasizing the need for additional research.
Understanding the halitosis and periodontitis association is clinically significant, informing potential interventions for improved oral health. Further research is vital to refine understanding and guide effective clinical strategies, acknowledging the limitations in current findings.
本系统评价和荟萃分析的目的是探讨观察性研究中口臭与牙周炎之间的关联。
系统搜索涵盖了 PubMed、Web of Science、Embase、Scopus 和 Cochrane Library，截至 2023 年 8 月 18 日。使用 Stata 17 分析了 9 项观察性研究（585 例病例，1591 例对照），使用比值比（ORs）和 95%置信区间（CIs）进行分析。亚组分析考虑了口臭评估方法。
综述发现口臭与牙周炎之间存在正相关。使用嗅觉测试（OR = 4.05，95%CI：1.76，9.30，p < 0.01）和挥发性硫化合物读数（OR = 4.52，95%CI：1.89，10.83，p < 0.01）时观察到显著差异。
口臭与牙周炎之间存在正相关，嗅觉和挥发性硫化合物读数均存在显著差异支持这一结论。然而，由于存在统计学异质性，结论受到限制，强调需要进一步研究。
了解口臭和牙周炎之间的关联具有临床意义，为改善口腔健康提供了潜在的干预措施。进一步的研究对于细化理解和指导有效的临床策略至关重要，同时也需要认识到当前研究结果的局限性。
