Department of Preventive Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Institute of Occupational and Environmental Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Yonsei Med J. 2024 Jun;65(6):363-370. doi: 10.3349/ymj.2023.0455.
We investigated the association between social support, metabolic syndrome, and incident cardio-cerebrovascular disease (CCVD) in rural Koreans aged ≥50 years.
We conducted a prospective study using the Korean Genome and Epidemiology Study on Atherosclerosis Risk of Rural Areas in the Korean General Population (KoGES-ARIRANG) dataset. From the baseline of 5169 adults, 1682 participants were finally included according to the exclusion criteria. For outcomes, myocardial infarction, angina, and stroke were included. For independent variables, the social support score and metabolic syndrome were used. Descriptive statistics and multivariate logistic regression were performed to investigate the association among the variables. Paired t-test was conducted to analyze the longitudinal variation of social support scores.
During the 6.37 years of median follow-up, 137 participants developed CCVD. The adjusted odds ratio (aOR) of metabolic syndrome with persistently high social support was 2.175 [95% confidence interval (CI): 1.479-3.119]. The aOR of metabolic syndrome with persistently low social support was 2.494 (95% CI: 1.141-5.452). The longitudinal variation of the social support score of persistently high social support group was increased significantly by 4.26±26.32. The score of the persistently low social support group was decreased by 1.34±16.87 with no statistical significance.
The presence of metabolic syndrome increases the likelihood of developing onset CCVD. Within the metabolic syndrome positive group, when social support was persistently low, the cohort developed more cardio-cerebrovascular disease compared to the persistently higher social support group. The social support score of the persistently low social support group could be improved through proper intervention. To prevent CCVD, metabolic syndrome components and low social support should be improved in the study participants.
我们研究了社会支持、代谢综合征与≥50 岁农村韩国人发生心脑血管疾病（CCVD）的关系。
我们使用韩国农村地区普通人群的韩国基因组和动脉粥样硬化风险的流行病学研究（KoGES-ARIRANG）数据集进行了一项前瞻性研究。在 5169 名成年人的基线中，根据排除标准最终纳入了 1682 名参与者。在结局方面，包括心肌梗死、心绞痛和中风。对于自变量，使用社会支持评分和代谢综合征。进行描述性统计和多变量逻辑回归以调查变量之间的关系。采用配对 t 检验分析社会支持评分的纵向变化。
在中位随访 6.37 年期间，137 名参与者发生了 CCVD。持续高社会支持的代谢综合征的校正比值比（aOR）为 2.175[95%置信区间（CI）：1.479-3.119]。持续低社会支持的代谢综合征的 aOR 为 2.494（95% CI：1.141-5.452）。持续高社会支持组的社会支持评分纵向变化显著增加了 4.26±26.32。持续低社会支持组的评分下降了 1.34±16.87，但无统计学意义。
代谢综合征的存在增加了发生心脑血管疾病的可能性。在代谢综合征阳性组中，当社会支持持续较低时，与持续较高的社会支持组相比，该队列发生更多的心血管疾病。通过适当的干预，可以改善持续低社会支持组的社会支持评分。为了预防 CCVD，应改善研究参与者的代谢综合征成分和低社会支持。
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