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Genetic predictors of traits in elderly subjects: risk of survival bias and reverse causation.

作者信息

Burgess Stephen, Zhou Ang

机构信息

MRC Biostatistics Unit, University of Cambridge, Robinson Way, Cambridge CB2 0SR, UK.

Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

出版信息

Eur Heart J. 2024 Jun 28;45(24):2155-2157. doi: 10.1093/eurheartj/ehae295.

DOI:10.1093/eurheartj/ehae295
PMID:38804264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11212826/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1ad/11212826/35ca6c607d45/ehae295_ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1ad/11212826/35ca6c607d45/ehae295_ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1ad/11212826/35ca6c607d45/ehae295_ga1.jpg

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本文引用的文献

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MR-SPLIT: A novel method to address selection and weak instrument bias in one-sample Mendelian randomization studies.MR-SPLIT:一种在单样本 Mendelian 随机化研究中解决选择偏倚和弱工具变量偏倚的新方法。
PLoS Genet. 2024 Sep 6;20(9):e1011391. doi: 10.1371/journal.pgen.1011391. eCollection 2024 Sep.
2
Non-linear Mendelian randomization: detection of biases using negative controls with a focus on BMI, Vitamin D and LDL cholesterol.非线性孟德尔随机化:使用阴性对照检测偏倚,重点关注 BMI、维生素 D 和 LDL 胆固醇。
Eur J Epidemiol. 2024 May;39(5):451-465. doi: 10.1007/s10654-024-01113-9. Epub 2024 May 25.
3
Body mass index, waist circumference, and mortality in subjects older than 80 years: a Mendelian randomization study.
80岁以上人群的体重指数、腰围与死亡率:一项孟德尔随机化研究
Eur Heart J. 2024 Jun 28;45(24):2145-2154. doi: 10.1093/eurheartj/ehae206.
4
Incorporating biological and clinical insights into variant choice for Mendelian randomisation: examples and principles.将生物学和临床见解纳入孟德尔随机化的变量选择:示例与原则
eGastroenterology. 2024 Jan;2(1):e100042. doi: 10.1136/egastro-2023-100042. Epub 2024 Jan 22.
5
Violation of the Constant Genetic Effect Assumption Can Result in Biased Estimates for Non-Linear Mendelian Randomization.违背常遗传效应假设可能导致非线性孟德尔随机化的有偏估计。
Hum Hered. 2023;88(1):79-90. doi: 10.1159/000531659. Epub 2023 Aug 31.
6
An empirical investigation into the impact of winner's curse on estimates from Mendelian randomization.孟德尔随机化中赢家诅咒对估计值影响的实证研究
Int J Epidemiol. 2023 Aug 2;52(4):1209-1219. doi: 10.1093/ije/dyac233.
7
The NHGRI-EBI GWAS Catalog: knowledgebase and deposition resource.NHGRI-EBI GWAS 目录:知识库和存储资源。
Nucleic Acids Res. 2023 Jan 6;51(D1):D977-D985. doi: 10.1093/nar/gkac1010.
8
Cross-fitted instrument: A blueprint for one-sample Mendelian randomization.交叉拟合工具:单一样本 Mendelian 随机化的蓝图。
PLoS Comput Biol. 2022 Aug 29;18(8):e1010268. doi: 10.1371/journal.pcbi.1010268. eCollection 2022 Aug.
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Bias due to participant overlap in two-sample Mendelian randomization.两样本孟德尔随机化中由于参与者重叠导致的偏倚。
Genet Epidemiol. 2016 Nov;40(7):597-608. doi: 10.1002/gepi.21998. Epub 2016 Sep 14.