Butler Forslund Emelie, Truong Minh Tat Nhat, Wang Ruoli, Seiger Åke, Gutierrez-Farewik Elena M
Department of Neurobiology, Care Science and Society, Karolinska Institutet, 141 83 Stockholm, Sweden.
Aleris Rehab Station R&D Unit, 169 89 Solna, Sweden.
Methods Protoc. 2024 May 4;7(3):39. doi: 10.3390/mps7030039.
This is a protocol for comprehensive analysis of gait and affecting factors in individuals with incomplete paraplegia due to spinal cord injury (SCI). A SCI is a devastating event affecting both sensory and motor functions. Due to better care, the SCI population is changing, with a greater proportion retaining impaired ambulatory function. Optimizing ambulatory function after SCI remains challenging. To investigate factors influencing optimal ambulation, a multi-professional research project was grounded with expertise from clinical rehabilitation, neurophysiology, and biomechanical engineering from Karolinska Institutet, the Spinalis Unit at Aleris Rehab Station (Sweden's largest center for specialized neurorehabilitation), and the Promobilia MoveAbility Lab at KTH Royal Institute of Technology. Ambulatory adults with paraplegia will be consecutively invited to participate. Muscle strength, sensitivity, and spasticity will be assessed, and energy expenditure, 3D movements, and muscle function (EMG) during gait and submaximal contractions will be analyzed. Innovative computational modeling and data-driven analyses will be performed, including the identification of clusters of similar movement patterns among the heterogeneous population and analyses that study the link between complex sensorimotor function and movement performance. These results may help optimize ambulatory function for persons with SCI and decrease the risk of secondary conditions during gait with a life-long perspective.
这是一项针对脊髓损伤（SCI）导致不全截瘫个体的步态及影响因素进行综合分析的方案。脊髓损伤是一种影响感觉和运动功能的灾难性事件。由于护理水平提高，脊髓损伤人群正在发生变化，更多人保留了受损的行走功能。脊髓损伤后优化行走功能仍然具有挑战性。为了研究影响最佳行走的因素，一个多专业研究项目基于卡罗林斯卡学院、瑞典最大的专业神经康复中心阿莱里斯康复站的脊髓单元以及皇家理工学院的Promobilia移动能力实验室的临床康复、神经生理学和生物力学工程专业知识开展。将连续邀请截瘫的成年行走者参与。将评估肌肉力量、感觉和痉挛情况，并分析步态和次最大收缩期间的能量消耗、三维运动和肌肉功能（肌电图）。将进行创新的计算建模和数据驱动分析，包括在异质人群中识别相似运动模式的聚类，以及研究复杂感觉运动功能与运动表现之间联系的分析。从长远来看，这些结果可能有助于优化脊髓损伤患者的行走功能，并降低步态期间继发疾病的风险。
