通过选择性修饰 N 端半胱氨酸与金属铱(III) 2-甲酰基苯硼酸配合物来构建光功能肽缀合物，用于细胞器特异性成像、酶活性传感和光动力治疗。
Construction of photofunctional peptide conjugates through selective modification of N-terminal cysteine with cyclometallated iridium(III) 2-formylphenylboronic acid complexes for organelle-specific imaging, enzyme activity sensing and photodynamic therapy.
机构信息
Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P. R. China.
Laboratory for Synthetic Chemistry and Chemical Biology Limited, Units 1503-1511, 15/F, Building 17 W, Hong Kong Science Park, New Territories, Hong Kong, P. R. China.
出版信息
Chem Commun (Camb). 2024 Jun 11;60(48):6186-6189. doi: 10.1039/d4cc01824a.
PMID:38805236
Abstract
Luminescent cyclometallated iridium(III) complexes bearing a 2-formylphenylboronic acid moiety were designed; one of the complexes was utilised to modify peptides containing an N-terminal cysteine to afford luminescent conjugates with selective organelle-targeting or furin-responsive properties.
摘要
设计了带有 2-甲酰基苯硼酸部分的发光的环金属铱（III）配合物；其中一个配合物用于修饰含有 N-末端半胱氨酸的肽，以提供具有选择性细胞器靶向或弗林响应性的发光缀合物。
相似文献
1
Construction of photofunctional peptide conjugates through selective modification of N-terminal cysteine with cyclometallated iridium(III) 2-formylphenylboronic acid complexes for organelle-specific imaging, enzyme activity sensing and photodynamic therapy.
Chem Commun (Camb). 2024 Jun 11;60(48):6186-6189. doi: 10.1039/d4cc01824a.
2
Tuning the organelle specificity and cytotoxicity of iridium(III) photosensitisers for enhanced phototheranostic applications.
Chem Commun (Camb). 2021 Nov 11;57(90):12008-12011. doi: 10.1039/d1cc04982h.
3
A Mitochondria-Targeted Photosensitizer Showing Improved Photodynamic Therapy Effects Under Hypoxia.
Angew Chem Int Ed Engl. 2016 Aug 16;55(34):9947-51. doi: 10.1002/anie.201604130. Epub 2016 Jul 6.
4
The stepwise photodamage of organelles by two-photon luminescent ruthenium(ii) photosensitizers.
Chem Commun (Camb). 2019 Sep 17;55(75):11235-11238. doi: 10.1039/c9cc05962h.
5
Long-wavelength triggered iridium(III) complex nanoparticles for photodynamic therapy against hypoxic cancer.
Chem Commun (Camb). 2024 Sep 10;60(73):9938-9941. doi: 10.1039/d4cc03501a.
6
Synthesis of pH-responsive cyclometalated iridium(III) complex and its application in the selective killing of cancerous cells.
Dalton Trans. 2021 Nov 30;50(46):17338-17345. doi: 10.1039/d1dt03042f.
7
Enhancing the tumor cell selectivity of a rhodamine-decorated iridium(III) complex by conjugating with indomethacin for COX-2 targeted photodynamic therapy.
Bioorg Chem. 2021 Sep;114:105142. doi: 10.1016/j.bioorg.2021.105142. Epub 2021 Jul 1.
8
Benzothiazole-decorated iridium-based nanophotosensitizers for photodynamic therapy of cancer cells.
Dalton Trans. 2022 Mar 1;51(9):3666-3675. doi: 10.1039/d1dt04315c.
9
Cyclometalated iridium(iii) complexes for mitochondria-targeted combined chemo-photodynamic therapy.
Dalton Trans. 2020 Mar 17;49(11):3562-3569. doi: 10.1039/d0dt00180e.
10
Photofunctional cyclometallated iridium(III) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications.
Chem Commun (Camb). 2022 Sep 13;58(73):10162-10165. doi: 10.1039/d2cc02405e.
引用本文的文献
1
Leveraging the Aminothiol-Specific Phosphorogenic Response of Iridium(III) Thioester Complexes for the Development of Intracellular Sensors and Cancer Phototherapeutics.
JACS Au. 2025 Jun 10;5(6):2825-2836. doi: 10.1021/jacsau.5c00413. eCollection 2025 Jun 23.
2
Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics.
Small Methods. 2024 Nov;8(11):e2400563. doi: 10.1002/smtd.202400563. Epub 2024 Sep 25.
Zotero 插件