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光功能化环金属铱(III)多吡啶甲砜配合物作为巯基特异性试剂在生物偶联、生物成像和光细胞毒性应用中的研究

Photofunctional cyclometallated iridium(III) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications.

机构信息

Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Hong Kong, P. R. China.

State Key Laboratory of Terahertz and Millimetre Waves, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P. R. China.

出版信息

Chem Commun (Camb). 2022 Sep 13;58(73):10162-10165. doi: 10.1039/d2cc02405e.

DOI:10.1039/d2cc02405e
PMID:35997227
Abstract

We report herein near-infrared (NIR)-emitting cyclometallated iridium(III) complexes bearing a heteroaromatic methylsulfone moiety as sulfhydryl-specific reagents; one of the complexes was conjugated to cysteine and cysteine-containing peptides and proteins for bioimaging and photocytotoxic applications.

摘要

我们在此报告了一类近红外（NIR）发射的环金属铱（III）配合物，它们带有杂芳基甲基砜部分作为巯基特异性试剂；其中一个配合物与半胱氨酸和含半胱氨酸的肽和蛋白质缀合，用于生物成像和光毒性应用。

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