pH 响应型环金属铱(III)配合物的合成及其在选择性杀伤癌细胞中的应用。
Synthesis of pH-responsive cyclometalated iridium(III) complex and its application in the selective killing of cancerous cells.
机构信息
Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710062, P.R. China.
出版信息
Dalton Trans. 2021 Nov 30;50(46):17338-17345. doi: 10.1039/d1dt03042f.
Cyclometalated iridium(III) complexes are promising candidates as photosensitizers (PSs) in photodynamic therapy (PDT). The challenge in PDT is the selective killing of cancerous cells over the neighboring normal cells. In this work, a pH-responsive cyclometalated iridium(III) complex (probe 1) was designed and synthesized as an effective PS to selectively kill cancerous cells, with 3-(2-pyridyl)benzaldehyde used as the main ligand and 1-(2-pyridyl)-β-carboline used as an ancillary ligand. Probe 1 shows enhanced photoluminescence emission and higher O quantum yield in an acidic environment compared to a neutral solution, which led to remarkable phototoxicity toward cancerous cells and high selectivity for killing cancerous cells over normal cells within 10 min. This work demonstrates that the cyclometalated iridium(III) complex with acidic pH-responsive photoluminescence emission and high O generation is an effective alternative PS for selectively killing cancerous cells.
金属环铱(III)配合物是光动力疗法(PDT)中很有前途的光敏剂(PS)。在 PDT 中面临的挑战是选择性地杀死癌细胞而不损伤邻近的正常细胞。在这项工作中，设计并合成了一种 pH 响应性金属环铱(III)配合物(探针 1)，用作有效的 PS 以选择性地杀死癌细胞，其中 3-(2-吡啶基)苯甲醛用作主配体，1-(2-吡啶基)-β-咔啉用作辅助配体。与中性溶液相比，探针 1 在酸性环境下表现出增强的光致发光发射和更高的 O 量子产率，这导致对癌细胞具有显著的光毒性，并在 10 分钟内对癌细胞具有高选择性杀伤，而对正常细胞无杀伤作用。这项工作表明，具有酸性 pH 响应性光致发光发射和高 O 生成的金属环铱(III)配合物是选择性杀伤癌细胞的有效替代 PS。
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