儿茶酚-O-甲基转移酶Val/Met基因多态性与精神分裂症阴性症状认知储备之间的相互作用
Interaction between catechol-O-methyltransferase Val/Met polymorphism and cognitive reserve for negative symptoms in schizophrenia.
作者信息
Hou Wen-Peng, Qin Xiang-Qin, Hou Wei-Wei, Han Yun-Yi, Bo Qi-Jing, Dong Fang, Zhou Fu-Chun, Li Xian-Bin, Wang Chuan-Yue
机构信息
Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China.
Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069, China.
出版信息
World J Psychiatry. 2024 May 19;14(5):695-703. doi: 10.5498/wjp.v14.i5.695.
BACKGROUND
Cognitive reserve (CR) and the catechol-O-methyltransferase () Val/Met polymorphism are reportedly linked to negative symptoms in schizophrenia. However, the regulatory effect of the genotype on the relationship between CR and negative symptoms is still unexamined.
AIM
To investigate whether the relationship between CR and negative symptoms could be regulated by the Val/Met polymorphism.
METHODS
In a cross-sectional study, 54 clinically stable patients with schizophrenia underwent assessments for the genotype, CR, and negative symptoms. CR was estimated using scores in the information and similarities subtests of a short form of the Chinese version of the Wechsler Adult Intelligence Scale.
RESULTS
Met-carriers exhibited fewer negative symptoms than Val homozygotes. In the total sample, significant negative correlations were found between negative symptoms and information, similarities. Associations between information, similarities and negative symptoms were observed in Val homozygotes only, with information and similarities showing interaction effects with the genotype in relation to negative symptoms (information, = -0.282, 95%CI: -0.552 to -0.011, = 0.042; similarities, = -0.250, 95%CI: -0.495 to -0.004, = 0.046).
CONCLUSION
This study provides initial evidence that the association between negative symptoms and CR is under the regulation of the genotype in schizophrenia.
背景
据报道，认知储备（CR）和儿茶酚-O-甲基转移酶（）Val/Met多态性与精神分裂症的阴性症状有关。然而，该基因多态性对CR与阴性症状之间关系的调节作用仍未得到研究。
目的
探讨CR与阴性症状之间的关系是否受Val/Met多态性的调节。
方法
在一项横断面研究中，对54例临床稳定的精神分裂症患者进行了该基因多态性、CR和阴性症状的评估。使用中文版韦氏成人智力量表简式的信息和相似性分测验得分来估计CR。
结果
携带Met等位基因者的阴性症状少于Val纯合子。在总样本中，阴性症状与信息、相似性之间存在显著负相关。仅在Val纯合子中观察到信息、相似性与阴性症状之间的关联，信息和相似性在阴性症状方面与该基因多态性存在交互作用（信息，β = -0.282，95%CI：-0.552至-0.011，P = 0.042；相似性，β = -0.250，95%CI：-0.495至-0.004，P = 0.046）。
结论
本研究提供了初步证据，表明精神分裂症中阴性症状与CR之间的关联受该基因多态性的调节。
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