Department of Integrated Chinese Traditional and Western Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Department of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Front Immunol. 2021 Jun 23;12:689044. doi: 10.3389/fimmu.2021.689044. eCollection 2021.
Autoimmune diseases are a worldwide health problem with growing rates of morbidity, and are characterized by breakdown and dysregulation of the immune system. Although their etiology and pathogenesis remain unclear, the application of dietary supplements is gradually increasing in patients with autoimmune diseases, mainly due to their positive effects, relatively safety, and low cost. Quercetin is a natural flavonoid that is widely present in fruits, herbs, and vegetables. It has been shown to have a wide range of beneficial effects and biological activities, including anti-inflammation, anti-oxidation, and neuroprotection. In several recent studies quercetin has reportedly attenuated rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, and systemic lupus erythematosus in humans or animal models. This review summarizes the evidence for the pharmacological application of quercetin for autoimmune diseases, which supports the view that quercetin may be useful for their prevention and treatment.
自身免疫性疾病是一个全球性的健康问题，发病率不断上升，其特征是免疫系统的崩溃和失调。尽管其病因和发病机制仍不清楚，但在自身免疫性疾病患者中，膳食补充剂的应用逐渐增加，主要是因为它们具有积极的作用、相对的安全性和低成本。槲皮素是一种广泛存在于水果、草药和蔬菜中的天然类黄酮，它具有广泛的有益作用和生物活性，包括抗炎、抗氧化和神经保护。最近的几项研究表明，槲皮素可减轻人类或动物模型中的类风湿性关节炎、炎症性肠病、多发性硬化症和系统性红斑狼疮。这篇综述总结了槲皮素在治疗自身免疫性疾病方面的药理学应用证据，支持了槲皮素可能对其预防和治疗有用的观点。
