Department for Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria.
Galen Research, Manchester, United Kingdom.
PLoS One. 2024 May 29;19(5):e0301483. doi: 10.1371/journal.pone.0301483. eCollection 2024.
Patients with pulmonary hypertension (PH) have an impaired functional capacity and poor health-related quality of life (HRQoL). The one-minute sit-to-stand test (1-min STST) can be used for the assessment of functional capacity.
Our aim was to evaluate the 1-min STST performance and its association with patient-reported HRQoL in patients with PH.
We prospectively assessed functional capacity in 98 PH patients (mean age 66 ± 15 years, 55% female) using the 1-min STST. Patients had to stand up and sit down from a chair as many times as possible within one minute. Patients' HRQoL was evaluated with the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) questionnaire, which consists of the three subcategories symptoms, activities and quality of life (QoL).
We observed a significant correlation of the 1-min STST performance with all HRQoL subcategories assessed with the CAMPHOR questionnaire: A lower number of 1-min STST repetitions correlated with more symptoms (rs = -.398, p < .001), worse functioning (rs = -.551, p < .001) and a decreased QoL (rs = -.407, p < .001). Furthermore, in the multivariable linear regression analysis, adjusted for age, sex, body mass index (BMI) and mean pulmonary artery pressure (mPAP), lower 1-min STST performance was an independent predictor for worse symptoms (est. β = -0.112, p = .003), activities (est. β = -0.198, p < .001) and QoL (est. β = -0.130, p < .001) assessed with the CAMPHOR questionnaire.
Our results indicate that regardless of age, sex, BMI and mPAP the 1-min STST performance is associated with all CAMPHOR HRQoL subcategories in patients with PH. Therefore, the 1-min STST performance might be a new option to assess functional capacity correlated to HRQoL in patients with PH.
患有肺动脉高压（PH）的患者的功能能力受损，健康相关生活质量（HRQoL）较差。1 分钟坐立试验（1-min STST）可用于评估功能能力。
我们的目的是评估 PH 患者的 1 分钟 STST 表现及其与患者报告的 HRQoL 的相关性。
我们前瞻性评估了 98 例 PH 患者（平均年龄 66 ± 15 岁，55%为女性）的功能能力，使用 1 分钟 STST。患者必须在一分钟内尽可能多地从椅子上站起来和坐下。患者的 HRQoL 通过剑桥肺动脉高压结局审查（CAMPHOR）问卷进行评估，该问卷由三个亚类组成：症状、活动和生活质量（QoL）。
我们观察到 1 分钟 STST 表现与 CAMPHOR 问卷评估的所有 HRQoL 亚类均存在显著相关性：1 分钟 STST 重复次数越少，症状越严重（rs = -.398，p <.001），功能障碍越严重（rs = -.551，p <.001），生活质量越低（rs = -.407，p <.001）。此外，在多元线性回归分析中，调整年龄、性别、体重指数（BMI）和平均肺动脉压（mPAP）后，较低的 1 分钟 STST 表现是症状（估计β=-.112，p=.003）、活动（估计β=-.198，p<.001）和 QoL（估计β=-.130，p<.001）的独立预测因子。
我们的结果表明，无论年龄、性别、BMI 和 mPAP 如何，1 分钟 STST 表现均与 PH 患者的所有 CAMPHOR HRQoL 亚类相关。因此，1 分钟 STST 表现可能是评估与 PH 患者 HRQoL 相关的功能能力的新选择。
