Molecular Cell Biology Department, Weizmann Institute of Science, Rehovot, Israel.
Cell Death Dis. 2024 May 29;15(5):371. doi: 10.1038/s41419-024-06766-8.
Apoptosis and ferroptosis are two regulated cell death (RCD) pathways implicated in different human diseases and considered as promising strategies to eliminate cancer cells. These two pathways are characterized by distinct morphological and biochemical properties, induce cell death through different mechanisms, but share common regulators in different cancer types. Although apoptosis and ferroptosis have been extensively studied over the last few years, their transcriptomic responses have not yet been systematically compared due to remarkable variability in the transcriptomic data. Here we provide a brief snapshot of the transcriptomic landscapes of the apoptosis and ferroptosis responses in cancer, discuss their divergent and convergent properties, and implications to cancer therapy.
细胞凋亡和铁死亡是两种与人类疾病相关的受调控的细胞死亡 (RCD) 途径，被认为是消除癌细胞的有前途的策略。这两种途径的特征在于形态和生化特性不同，通过不同的机制诱导细胞死亡，但在不同类型的癌症中共享共同的调节剂。尽管凋亡和铁死亡在过去几年中得到了广泛研究，但由于转录组数据的显著变异性，它们的转录组反应尚未得到系统比较。在这里，我们简要概述了癌症中凋亡和铁死亡反应的转录组景观，讨论了它们的发散和收敛特性及其对癌症治疗的影响。
