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纳米诊疗学在癌症应用中的最新进展

Recent Advancement of Nanotheranostics in Cancer Applications.

作者信息

Parveen Suphiya, Abira R, Paikray Safal, Sahoo Liza, Tripathy Nigam Sekahr, Dilnawaz Fahima

机构信息

Department of Biotechnology and Genetics, School of Sciences, Jain (Deemed-to-be-University), Bengaluru, Karnataka- 560027, India.

School of Biotechnology, Centurion University of Technology and Management, Jatni, Bhubaneswar-752050, Odisha, India.

出版信息

Curr Drug Deliv. 2024 May 29. doi: 10.2174/0115672018307617240514092110.

Abstract

The field of nanomedicine shows promising implications in the concurrent delivery of therapeutic and diagnostic (theranostics) compounds in a single platform. Nanotheranostics is incredibly promising since it offers simultaneous non-invasive disease detection and treatment together with the exciting ability to track drug release and distribution in real-time, thereby forecasting and evaluating the efficacy of the therapy. The cancer theranostic approach improves the cancer prognosis safely and effectively. Common classes of nanoscale biomaterials, including magnetic nanoparticles, quantum dots, upconversion nanoparticles, mesoporous silica nanoparticles, carbon- based nanoparticles, and organic dye-based nanoparticles, have demonstrated enormous potential for theranostic activity. The need for improved disease detection and enhanced chemotherapeutic treatments, together with realistic considerations for clinically translatable nanomaterials will be key driving factors for theranostic agent research shortly. The developments of precision theranostic nanomaterials are employed in imaging systems like, MRI, PET, and SPECT with multifunctional ability. In this review, different nanoparticles/nanomaterials that are used/developed for theranostic activity are discussed.

摘要

纳米医学领域在单一平台上同时递送治疗性和诊断性(治疗诊断)化合物方面显示出了广阔的应用前景。纳米治疗诊断学极具潜力,因为它能同时实现非侵入性疾病检测与治疗,还具备实时追踪药物释放和分布的惊人能力,从而预测和评估治疗效果。癌症治疗诊断方法能安全有效地改善癌症预后。常见的纳米级生物材料类别,包括磁性纳米颗粒、量子点、上转换纳米颗粒、介孔二氧化硅纳米颗粒、碳基纳米颗粒和有机染料基纳米颗粒,已展现出巨大的治疗诊断活性潜力。对改善疾病检测和强化化疗治疗的需求,以及对临床可转化纳米材料的实际考量,将是近期治疗诊断剂研究的关键驱动因素。精准治疗诊断纳米材料的发展应用于具有多功能能力的成像系统,如磁共振成像(MRI)、正电子发射断层扫描(PET)和单光子发射计算机断层扫描(SPECT)。在这篇综述中,将讨论用于治疗诊断活性的不同纳米颗粒/纳米材料。

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