Institute of Tissue Regeneration Engineering (ITREN), Dankook University , Cheonan 330-714, South Korea.
Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University , Cheonan 330-714, South Korea.
ACS Appl Mater Interfaces. 2017 Mar 29;9(12):10309-10337. doi: 10.1021/acsami.6b16505. Epub 2017 Mar 16.
Theranostics based on nanoparticles (NPs) is a promising paradigm in nanomedicine. Mesoporous silica nanoparticle (MSN)-based systems offer unique characteristics to enable multimodal imaging or simultaneous diagnosis and therapy. They include large surface area and volume, tunable pore size, functionalizable surface, and acceptable biological safety. Hybridization with other NPs and chemical modification can further potentiate the multifunctionality of MSN-based systems toward translation. Here, we update the recent progress on MSN-based systems for theranostic purposes. We discuss various synthetic approaches used to construct the theranostic platforms either via intrinsic chemistry or extrinsic combination. These include defect generation in the silica structure, encapsulation of diagnostic NPs within silica, their assembly on the silica surface, and direct conjugation of dye chemicals. Collectively, in vitro and in vivo results demonstrate that multimodal imaging capacities can be integrated with the therapeutic functions of these MSN systems for therapy. With further improvement in bioimaging sensitivity and targeting specificity, the multifunctional MSN-based theranostic systems will find many clinical applications in the near future.
基于纳米粒子（NPs）的治疗学是纳米医学中一个很有前途的范例。介孔硅纳米粒子（MSN）为多模式成像或同时诊断和治疗提供了独特的特性。它们包括大的表面积和体积、可调的孔径、功能化的表面和可接受的生物安全性。与其他 NPs 的杂交和化学修饰可以进一步增强 MSN 基系统的多功能性，以促进转化。在这里，我们更新了基于 MSN 的治疗系统的最新进展。我们讨论了各种用于构建治疗学平台的合成方法，这些方法要么通过内在化学，要么通过外在组合。这些方法包括在硅结构中产生缺陷、将诊断性 NPs 封装在硅中、将其组装在硅表面上以及直接将染料化学物质偶联。总之，体外和体内的结果表明，这些 MSN 系统的多模式成像能力可以与治疗功能相结合，用于治疗。随着生物成像灵敏度和靶向特异性的进一步提高，多功能 MSN 基治疗系统将在不久的将来在临床上得到广泛应用。
