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优化剖宫产结局的循证外科手术:系统评价概述

Evidence-based surgical procedures to optimize caesarean outcomes: an overview of systematic reviews.

作者信息

Gialdini Celina, Chamillard Monica, Diaz Virginia, Pasquale Julia, Thangaratinam Shakila, Abalos Edgardo, Torloni Maria Regina, Betran Ana Pilar

机构信息

Centro Rosarino de Estudios Perinatales (CREP), Rosario, Argentina.

Facultat de Ciències de la Salut Blanquerna, Universitat Ramon Llull, Barcelona, Spain.

出版信息

EClinicalMedicine. 2024 May 19;72:102632. doi: 10.1016/j.eclinm.2024.102632. eCollection 2024 Jun.


DOI:10.1016/j.eclinm.2024.102632
PMID:38812964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11134562/
Abstract

BACKGROUND: Caesarean section (CS) is the most performed major surgery worldwide. Surgical techniques used for CS vary widely and there is no internationally accepted standardization. We conducted an overview of systematic reviews (SR) of randomized controlled trials (RCT) to summarize the evidence on surgical techniques or procedures related to CS. METHODS: Searches were conducted from database inception to 31 January 2024 in Cochrane Database of Systematic Reviews, PubMed, EMBASE, Lilacs and CINAHL without date or language restrictions. AMSTAR 2 and GRADE were used to assess the methodological quality of the SRs and the certainty of evidence at outcome level, respectively. We classified each procedure-outcome pair into one of eight categories according to effect estimates and certainty of evidence. The overview was registered at PROSPERO (CRD 42023208306). FINDINGS: The analysis included 38 SRs (16 Cochrane and 22 non-Cochrane) published between 2004-2024 involving 628 RCT with a total of 190,349 participants. Most reviews were of low or critically low quality (AMSTAR 2). The SRs presented 345 procedure-outcome comparisons (237 procedure versus procedure, 108 procedure versus no treatment/placebo). There was insufficient or inconclusive evidence for 256 comparisons, clear evidence of benefit for 40, possible benefit for 17, no difference of effect for 13, clear evidence of harm for 14, and possible harm for 5. We found no SRs for 7 pre-defined procedures. Skin cleansing with chlorhexidine, Joel-Cohen-based abdominal incision, uterine incision with blunt dissection and cephalad-caudal expansion, cord traction for placental extraction, manual cervical dilatation in pre-labour CS, changing gloves, chromic catgut suture for uterine closure, non-closure of the peritoneum, closure of subcutaneous tissue, and negative pressure wound therapy are procedures associated with benefits for relevant outcomes. INTERPRETATION: Current evidence suggests that several CS surgical procedures improve outcomes but also reveals a lack of or inconclusive evidence for many commonly used procedures. There is an urgent need for evidence-based guidelines standardizing techniques for CS, and trials to fill existing knowledge gaps. FUNDING: UNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), a cosponsored programme executed by the World Health Organization (WHO).

摘要

背景:剖宫产是全球实施最多的大型手术。用于剖宫产的手术技术差异很大,且没有国际公认的标准化方法。我们对随机对照试验的系统评价进行了综述,以总结与剖宫产相关的手术技术或操作的证据。 方法:从数据库建立至2024年1月31日,在Cochrane系统评价数据库、PubMed、EMBASE、Lilacs和CINAHL中进行检索,无日期或语言限制。分别使用AMSTAR 2和GRADE评估系统评价的方法学质量和结局水平证据的确定性。根据效应估计和证据确定性,将每个程序 - 结局对分为八类之一。该综述已在PROSPERO(CRD 42023208306)注册。 结果:分析纳入了2004年至2024年发表的38篇系统评价(16篇Cochrane系统评价和22篇非Cochrane系统评价),涉及628项随机对照试验,共190349名参与者。大多数综述质量低或极低(AMSTAR 2)。这些系统评价呈现了345个程序 - 结局比较(237个程序与程序比较,108个程序与未治疗/安慰剂比较)。2

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be74/11134562/baef0986d273/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be74/11134562/baef0986d273/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be74/11134562/baef0986d273/gr1.jpg

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[1]
Evidence-based surgical procedures to optimize caesarean outcomes: an overview of systematic reviews.

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[6]
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[8]
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[9]
Negative pressure wound therapy for surgical wounds healing by primary closure.

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[10]
Negative pressure wound therapy for surgical wounds healing by primary closure.

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引用本文的文献

[1]
Surgical site infections after caesarean section across sub-Sahara Africa: a scoping review of prevalence and associated factors.

Front Glob Womens Health. 2025-7-1

[2]
Evidence-based medical procedures to optimise caesarean outcomes: an overview of systematic reviews.

EClinicalMedicine. 2025-4-30

[3]
Ultrasound outcomes and surgical parameters of the double-layer purse-string uterine closure technique in cesarean delivery: a systematic review and meta-analysis of randomized trials.

BMC Surg. 2025-2-8

[4]
Complex cesarean section: Surgical approach to reduce the risks of intraoperative complications and postpartum hemorrhage.

Int J Gynaecol Obstet. 2025-3

[5]
Enhancing Postoperative Analgesia After Cesarean Section: Insights Into Transversus Abdominis Plane Block, Intrathecal Opioids, and Other Analgesic Techniques.

Cureus. 2024-10-31

本文引用的文献

[1]
Management of impacted fetal head at cesarean delivery.

Am J Obstet Gynecol. 2024-3

[2]
Low-Value Surgical Procedures in Low- and Middle-Income Countries: A Systematic Scoping Review.

JAMA Netw Open. 2023-11-1

[3]
Subcuticular Suture Type at Cesarean Delivery and Infection Risk: A Systematic Review and Meta-Analysis.

J Obstet Gynaecol Can. 2024-1

[4]
Surgical trial design for incorporating the effects of learning: what is the current methodological guidance, and is it sufficient?

Trials. 2023-4-25

[5]
Spontaneous versus manual placental delivery during cesarean delivery: a systematic review and meta-analysis.

J Matern Fetal Neonatal Med. 2022-12

[6]
Suture type for hysterotomy closure: a systematic review and meta-analysis of randomized controlled trials.

Am J Obstet Gynecol MFM. 2022-11

[7]
Reporting guideline for overviews of reviews of healthcare interventions: development of the PRIOR statement.

BMJ. 2022-8-9

[8]
Suture Compared With Staples for Skin Closure After Cesarean Delivery: A Systematic Review and Meta-analysis.

Obstet Gynecol. 2022-8-1

[9]
Comparison of the effect of skin closure materials on skin closure during cesarean delivery.

PLoS One. 2022

[10]
Knotless Barbed versus Conventional Suture for Closure of the Uterine Incision at Cesarean Delivery: A Systematic Review and Meta-analysis.

J Minim Invasive Gynecol. 2022-7

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