Kaliamoorthy Sriram, Priya Sayeeram Sugantha, Gowdhaman N, Jayaraj Merlin, Radhika B, Chellapandi Sugirtha, Elumalai Agila, Archana Sai P, Raju Kanmani, Palla Santosh
Department of Dentistry, Vinayaka Missions Medical College and Hospital, Vinayaka Missions Research Foundation, Karaikal, IND.
Department of Prosthodontics, Government Dental College and Hospital, The Tamil Nadu Dr. MGR Medical University, Pudukkottai, IND.
Cureus. 2024 Apr 29;16(4):e59251. doi: 10.7759/cureus.59251. eCollection 2024 Apr.
is the primary microbe in the "periodontal red complex" bacteria (PRCB) along with and , which are linked to periodontal disease (PD). These pathogens are also implicated in various systemic disorders, but their association with the incidence of gastrointestinal (GI) cancer is less explored. A systematic review followed by a meta-analysis was conducted as per standard guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2022) to find this association between GI cancers and PRCB after a literature search for full-text papers in the English language (between 2010 and 2023) in databases (Cochrane Library, PubMed, and Web of Science) with suitable keywords using the Boolean search strategy. Data extraction involved titles, abstracts, and full texts retrieved and scored by the modified Newcastle-Ottawa Scale. The data were analyzed by the Review Manager (RevMan 5.2, Cochrane Collaboration, Denmark). Standard Cochran Q test and I statistics (for heterogeneity) and a random effects model (pooled OR with 95% CI) were applied to report results. among the PRCB was linked to GI cancers (OR: 2.16; 95% CI: 1.34-3.47). and did not show meaningful associations as per existing evidence for GI cancers.
是“牙周红色复合体”细菌（PRCB）中的主要微生物，与和一起，它们与牙周病（PD）有关。这些病原体还与各种全身性疾病有关，但它们与胃肠道（GI）癌发病率的关联研究较少。按照标准指南（系统评价和Meta分析的首选报告项目（PRISMA）2022）进行了系统评价，随后进行Meta分析，以在数据库（Cochrane图书馆、PubMed和科学网）中使用布尔搜索策略以英文（2010年至2023年之间）搜索全文论文后，找出GI癌与PRCB之间的这种关联。数据提取涉及使用改良的纽卡斯尔-渥太华量表检索和评分的标题、摘要和全文。数据由Review Manager（RevMan 5.2，Cochrane协作网，丹麦）进行分析。应用标准Cochran Q检验和I统计量（用于异质性）以及随机效应模型（合并OR值及95%CI）报告结果。PRCB中的与GI癌有关（OR：2.16；95%CI：1.34 - 3.47）。根据现有证据，和与GI癌没有显示出有意义的关联。
