UAB Vilnius Implantology Center Clinic, A. Vivulskio Str. 7-102, LT-03162 Vilnius, Lithuania.
Department of Dental and Oral Pathology, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50161 Kaunas, Lithuania.
Medicina (Kaunas). 2023 Nov 28;59(12):2088. doi: 10.3390/medicina59122088.
: More than a billion people worldwide suffer from chronic periodontitis. The primary etiological factor of periodontal diseases is dental plaque and the bacteria it contains, particularly , , , , and . Zinc, owing to its antibacterial properties, can be employed in periodontology. The objective of this review was to analyze scientific literature that examines the effects of zinc on periopathogens. : A systematic review protocol of scientific literature was designed following PRISMA recommendations. Data search was conducted in PubMed, Web of Science, and ScienceDirect databases. Full-text articles in English that examine the effects of zinc on periopathogens and were published between 2011 and 2021 were included. Fifteen articles were included in the analysis based on inclusion criteria. ZnO exhibited antibacterial activity against and ( < 0.001). The minimum inhibitory concentration against was 10 μg/mL. ZnO demonstrated a significant antibacterial effect, as evidenced by inhibition zones of 15.10 mm for , 13.36 mm for , 12.98 mm for , and 14.01 mm for Zn (II)-based polymers inhibited the and genes of . Titanium dental implants coated with ZnO effectively disrupted the cell walls of and . ZnO inhibited the growth of within 2 h and the growth of and within 3 h. ZnO exhibited nontoxic effects, and concentrations up to 0.8 mg/L increased cell survival rates by up to 90%. The analysis of the literature confirms the antibacterial action of zinc against periodontal pathogenic bacteria. At low concentrations, these substances do not exhibit cytotoxic effects on fibroblasts.
全世界有超过 10 亿人患有慢性牙周炎。牙周病的主要病因是牙菌斑及其所含的细菌，特别是 、 、 、 、 。锌由于其抗菌特性，可用于牙周病学。本综述的目的是分析研究锌对牙周病原菌影响的科学文献。
按照 PRISMA 建议设计了科学文献系统评价方案。在 PubMed、Web of Science 和 ScienceDirect 数据库中进行了数据搜索。纳入了 2011 年至 2021 年期间发表的、以英文撰写的、研究锌对牙周病原菌影响的全文文章。根据纳入标准，有 15 篇文章被纳入分析。氧化锌对 和 具有抗菌活性（<0.001）。对 的最小抑菌浓度为 10μg/ml。氧化锌表现出显著的抗菌作用，抑菌环分别为 15.10mm 用于 ，13.36mm 用于 ，12.98mm 用于 ，14.01mm 用于 Zn（II）基聚合物抑制 和 的基因。涂有氧化锌的钛牙科植入物有效地破坏了 和 的细胞壁。氧化锌在 2 小时内抑制 的生长，在 3 小时内抑制 和 的生长。氧化锌表现出非毒性作用，浓度高达 0.8mg/L 时，细胞存活率提高了 90%。
文献分析证实了锌对牙周病原菌的抗菌作用。在低浓度下，这些物质对成纤维细胞没有细胞毒性作用。
