Department of Pharmacology, College of Pharmacy, Al-Esraa University, Baghdad, Iraq.
Department of Clinical Pharmacy, College of Pharmacy, Al-Nahrain University, Baghdad, Iraq.
J Med Life. 2024 Feb;17(2):157-163. doi: 10.25122/jml-2023-0343.
Aging, a complex physiological process affecting all living things, is a major area of research, particularly focused on interventions to slow its progression. This study assessed the antiaging efficacy of dapagliflozin (DAPA) on various aging-related parameters in a mouse model artificially induced to age. Forty male Swiss albino mice were randomly divided into four groups of ten animals each. The control group (Group I) received normal saline. The aging model group (Group II) was administered D-galactose orally at 500mg/kg to induce aging. Following the aging induction, the positive control group received Vitamin C supplementation (Group III), while the DAPA group (Group IV) was treated with dapagliflozin. The inflammatory mediators (TNF-α and IL-1β) showed similar patterns of change. No statistically significant difference was observed between groups III and IV. Both groups had significantly lower values compared to GII, while it was significantly higher compared to GI. Glutathione peroxidase (GSH-Px) showed no statistically significant difference between groups GIII and GIV, but it was higher in GIII compared to GII and significantly lower in GIII compared to GI. The study demonstrated that dapagliflozin exerts a beneficial impact on many indicators of aging in mice. The intervention resulted in a reduction in hypertrophy in cardiomyocytes, an enhancement in skin vitality, a decrease in the presence of inflammatory mediators, and an improvement in the efficacy of antioxidants.
衰老，一种影响所有生物的复杂生理过程，是一个主要的研究领域，特别是集中在干预措施以减缓其进展。本研究评估了达格列净（DAPA）对人工诱导衰老的小鼠模型中各种与衰老相关参数的抗衰老疗效。40 只雄性瑞士白化病小鼠被随机分为四组，每组 10 只动物。对照组（I 组）给予生理盐水。衰老模型组（II 组）给予 500mg/kg 的 D-半乳糖口服以诱导衰老。衰老诱导后，阳性对照组给予维生素 C 补充（III 组），而 DAPA 组（IV 组）给予达格列净治疗。炎症介质（TNF-α和 IL-1β）表现出相似的变化模式。III 组和 IV 组之间没有统计学差异。与 GII 相比，两组的数值均显著降低，而与 GI 相比，两组的数值均显著升高。谷胱甘肽过氧化物酶（GSH-Px）在 GIII 和 GIV 组之间没有统计学差异，但与 GII 相比，GIII 组的数值更高，与 GI 相比，GIII 组的数值显著更低。研究表明，达格列净对小鼠的许多衰老指标都有有益的影响。该干预措施导致心肌细胞肥大减少，皮肤活力增强，炎症介质的存在减少，抗氧化剂的功效改善。
