紫外线照射的大肠杆菌中导致lacI突变的光产物的身份。
Identity of the photoproduct that causes lacI mutations in UV-irradiated Escherichia coli.
作者信息
Lawrence C W, Christensen R B, Christensen J R
出版信息
J Bacteriol. 1985 Feb;161(2):767-8. doi: 10.1128/jb.161.2.767-768.1985.
Abstract
Estimates of the capacity of photoreactivation to act specifically on premutational lesions were obtained by conjugational transfer of an F' lac plasmid from a UV-irradiated, photoreactivated donor to a delta (pro-lac) recipient that had been UV irradiated and allowed to induce SOS functions for 30 min. This treatment reduced the frequency of induced lacI mutations by 70 to 80%, indicating that cyclobutane dimers cause most mutations in this system.
摘要
通过将F' lac质粒从紫外线照射且经光复活处理的供体进行接合转移至经紫外线照射并允许诱导SOS功能30分钟的δ（pro-lac）受体，获得了光复活作用特异性作用于前突变损伤的能力估计值。这种处理使诱导的lacI突变频率降低了70%至80%，表明环丁烷二聚体在该系统中导致了大多数突变。
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本文引用的文献
1
UV-induced mutation hotspots occur at DNA damage hotspots.紫外线诱导的突变热点出现在DNA损伤热点处。
Nature. 1982 Jul 8;298(5870):189-92. doi: 10.1038/298189a0.
2
The role of pyrimidine dimers as premutagenic lesions: a study of targeted vs. untargeted mutagenesis in the lacI gene of Escherichia coli.嘧啶二聚体作为前诱变损伤的作用：大肠杆菌lacI基因中靶向诱变与非靶向诱变的研究。
Genetics. 1984 Mar;106(3):347-64. doi: 10.1093/genetics/106.3.347.
3
Control of UV induction of recA protein.recA蛋白紫外线诱导的调控
Proc Natl Acad Sci U S A. 1983 Jan;80(1):65-9. doi: 10.1073/pnas.80.1.65.
4
Cleavage of pyrimidine dimers in specific DNA sequences by a pyrimidine dimer DNA-glycosylase of M. luteus.藤黄微球菌的嘧啶二聚体DNA糖基化酶对特定DNA序列中嘧啶二聚体的切割作用
Nature. 1980 Jun 26;285(5767):634-41. doi: 10.1038/285634a0.
5
Changes in DNA base sequence induced by targeted mutagenesis of lambda phage by ultraviolet light.紫外线对λ噬菌体进行靶向诱变所诱导的DNA碱基序列变化。
J Mol Biol. 1984 Mar 5;173(3):273-91. doi: 10.1016/0022-2836(84)90121-9.
6
Cleavage of lambda repressor and synthesis of RecA protein induced by transferred UV-damaged F sex factor.转移的紫外线损伤F性因子诱导λ阻遏物的裂解和RecA蛋白的合成。
Mol Gen Genet. 1982;186(2):170-9. doi: 10.1007/BF00331847.
7
Near-U.V. photolysis of pyrimidine heteroadducts in E. coli DNA.
Photochem Photobiol. 1970 Jun;11(6):477-85. doi: 10.1111/j.1751-1097.1970.tb06018.x.
8
Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.大肠杆菌中的紫外线诱变与诱导性DNA修复
Bacteriol Rev. 1976 Dec;40(4):869-907. doi: 10.1128/br.40.4.869-907.1976.
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