Kipkemoi Patricia, Savage Jeanne E, Gona Joseph, Rimba Kenneth, Kombe Martha, Mwangi Paul, Kipkoech Collins, Posthuma Danielle, Newton Charles R J C, Abubakar Amina
Neuroscience Unit, KEMRI-Wellcome Trust Research Programme, P.O Box 230-80108, Kilifi, Kenya.
Complex Trait Genetics Department, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
J Autism Dev Disord. 2024 May 30. doi: 10.1007/s10803-024-06380-9.
Children can be reliably diagnosed with autism as early as 3 years of age, and early interventions are initiated. There is often a significant gap between the age of onset of symptoms (2-3 years) and diagnosis (8-10 years) in Africa. We conducted a study to validate the Social Communication Questionnaire (SCQ) as a screening instrument in a rural setting in Kenya. The study was conducted along the Kenyan Coast. Study participants included 172 children with a neurodevelopmental disorder (NDD) diagnosis (84 of which were autism) and 112 controls. Internal consistency was evaluated through the use of Cronbach's alpha, confirmatory factor analysis (CFA) with maximum likelihood procedure to assess the conceptual model for the SCQ. Additionally, the sensitivity and specificity of cut-off scores using ROC analysis and item difficulties and discrimination quality using an IRT framework were also assessed. Factor analysis revealed an adequate fitting model for the three-factor DSM-IV-TR (root mean squared error of approximation (RMSEA) = 0.050; Comparative Fit Index (CFI) = 0.974; Tucker-Lewis Index (TLI) = 0.973) and two-factor DSM-5 factor structure (RMSEA = 0.050; CFI = 0.972; TLI = 0.974). The reliability coefficient alphas for the whole group for all items (Cronbach's α = 0.90) and all three domains (Cronbach's α = 0.68-0.84) were acceptable to excellent. The recommended cut-off score of 15 yielded 72% sensitivity and 100% specificity in the ASD group compared to the typically developing group. We provide early evidence of the adequate factor structure and good internal consistency of the SCQ. We also note that the recommended cut-off yielded sufficient predictive validity.
儿童早在3岁时就能被可靠地诊断出自闭症,并开始进行早期干预。在非洲,症状出现的年龄(2至3岁)与诊断年龄(8至10岁)之间往往存在显著差距。我们开展了一项研究,以验证社交沟通问卷(SCQ)作为肯尼亚农村地区筛查工具的有效性。该研究在肯尼亚海岸沿线进行。研究参与者包括172名被诊断患有神经发育障碍(NDD)的儿童(其中84名是自闭症)和112名对照。通过使用克朗巴哈系数评估内部一致性,采用最大似然法进行验证性因子分析(CFA)以评估SCQ的概念模型。此外,还使用ROC分析评估了临界值分数的敏感性和特异性,并使用IRT框架评估了项目难度和区分度质量。因子分析显示,三因素DSM-IV-TR模型拟合良好(近似均方根误差(RMSEA)=0.050;比较拟合指数(CFI)=0.974;塔克-刘易斯指数(TLI)=0.973),两因素DSM-5因子结构拟合也良好(RMSEA=0.050;CFI=0.972;TLI=0.974)。所有项目的全组可靠性系数α(克朗巴哈系数α=0.90)以及所有三个领域的可靠性系数α(克朗巴哈系数α=0.68至0.84)均为可接受至优秀水平。与正常发育组相比,推荐的临界值分数15在自闭症谱系障碍(ASD)组中产生了72%的敏感性和100%的特异性。我们提供了SCQ具有适当因子结构和良好内部一致性的早期证据。我们还注意到,推荐的临界值产生了足够的预测效度。