NAT10 和 mRNA 中的胞嘧啶乙酰化：发育和疾病中的交集。
NAT10 and cytidine acetylation in mRNA: intersecting paths in development and disease.
机构信息
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 USA.
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 USA.
出版信息
Curr Opin Genet Dev. 2024 Aug;87:102207. doi: 10.1016/j.gde.2024.102207. Epub 2024 May 30.
N4-acetylcytidine (ac4C) is an RNA modification that is catalyzed by the enzyme NAT10. Constitutively found in tRNA and rRNA, ac4C displays a dynamic presence in mRNA that is shaped by developmental and induced shifts in NAT10 levels. However, deciphering ac4C functions in mRNA has been hampered by its context-dependent influences in translation and the complexity of isolating effects on specific mRNAs from other NAT10 activities. Recent advances have begun to overcome these obstacles by leveraging natural variations in mRNA acetylation in cancer, developmental transitions, and immune responses. Here, we synthesize the current literature with a focus on nuances that may fuel the perception of cellular discrepancies toward the development of a cohesive model of ac4C function in mRNA.
N4-乙酰胞苷（ac4C）是一种由酶 NAT10 催化的 RNA 修饰。ac4C 普遍存在于 tRNA 和 rRNA 中，在 mRNA 中呈现动态存在，其水平受 NAT10 水平的发育和诱导变化所影响。然而，由于 ac4C 在翻译中的上下文依赖性影响以及从其他 NAT10 活性中分离特定 mRNA 的影响的复杂性，破译 mRNA 中的 ac4C 功能受到了阻碍。最近的进展开始通过利用癌症、发育转变和免疫反应中 mRNA 乙酰化的自然变异来克服这些障碍。在这里，我们综合了当前的文献，重点关注可能导致人们对细胞差异产生误解的细微差别，以形成一个关于 ac4C 在 mRNA 中功能的统一模型。
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