全面探讨小核仁 RNA（snoRNAs）和 SNHGs 在人类癌症中的作用。
A comprehensive insight into the role of small nucleolar RNAs (snoRNAs) and SNHGs in human cancers.
机构信息
Department of Physiology, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia.
Department of Pharmaceutical Analysis, Chaitanya Deemed to be University, Hanamkonda, India.
出版信息
Pathol Res Pract. 2023 Sep;249:154679. doi: 10.1016/j.prp.2023.154679. Epub 2023 Jul 16.
Long non-coding RNAs (lncRNAs), which comprise most non-coding RNAs (ncRNAs), have recently become a focus of cancer research. How many functional ncRNAs exist is still a matter of debate. Although insufficient evidence supports that most lncRNAs function as transcriptional by-products, it is widely known that an increasing number of lncRNAs play essential roles in cells. Small nucleolar RNAs (snoRNAs), 60-300 nucleotides in length, have been better studied than long non-coding RNAs (lncRNAs) and are predominantly present in the nucleolus. Most snoRNAs are encoded in introns of protein- and non-protein-coding genes called small nucleolar RNA host genes (SNHGs). In this article, we explore the biology and characteristics of SNHGs and their role in developing human malignancies. In addition, we provide an update on the ability of these snoRNAs to serve as prognostic and diagnostic variables in various forms of cancer.
长链非编码 RNA（lncRNA）是大多数非编码 RNA（ncRNA）的组成部分，最近成为癌症研究的焦点。有多少种功能性 ncRNA 仍然存在争议。虽然没有足够的证据支持大多数 lncRNA 作为转录副产物发挥作用，但越来越多的 lncRNA 在细胞中发挥着重要作用是众所周知的。小核仁 RNA（snoRNA）长度为 60-300 个核苷酸，比长链非编码 RNA（lncRNA）研究得更充分，主要存在于核仁中。大多数 snoRNA 编码在称为小核仁 RNA 宿主基因（SNHG）的蛋白质和非蛋白质编码基因的内含子中。在本文中，我们探讨了 SNHG 的生物学和特征及其在人类恶性肿瘤发展中的作用。此外，我们还介绍了这些 snoRNA 作为各种癌症的预后和诊断变量的能力的最新进展。
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