Fujian Key Laboratory of Polymer Materials, College of Chemistry and Materials Science, Fujian Normal University, Fujian 350007, China.
Fujian Key Laboratory of Polymer Materials, College of Chemistry and Materials Science, Fujian Normal University, Fujian 350007, China.
Int J Biol Macromol. 2024 Jun;271(Pt 2):132559. doi: 10.1016/j.ijbiomac.2024.132559. Epub 2024 May 31.
Massive bleeding resulting from civil and martial accidents can often lead to shock or even death, highlighting the critical need for the development of rapid and efficient hemostatic materials. While various types of hemostatic materials are currently utilized in clinical practice, they often come with limitations such as poor biocompatibility, toxicity, and biodegradability. Polysaccharides, such as alginate (AG), chitosan (CS), cellulose, starch, hyaluronic acid (HA), and dextran, have exhibit excellent biocompatibility and in vivo biodegradability. Their degradation products are non-toxic to surrounding tissues and can be absorbed by the body. As a result, polysaccharides have been extensively utilized in the development of hemostatic materials and have gained significant attention in the field of in vivo hemostasis. This review offers an overview of the different forms, hemostatic mechanisms, and specific applications of polysaccharides. Additionally, it discusses the future opportunities and challenges associated with polysaccharide-based hemostats.
大量因民事和军事事故导致的出血往往会导致休克甚至死亡，这凸显了开发快速有效的止血材料的紧迫性。虽然目前在临床实践中使用了各种类型的止血材料，但它们通常存在生物相容性差、毒性和生物降解性差等局限性。多糖，如藻酸盐（AG）、壳聚糖（CS）、纤维素、淀粉、透明质酸（HA）和葡聚糖，具有优异的生物相容性和体内生物降解性。其降解产物对周围组织无毒，可被人体吸收。因此，多糖已被广泛应用于止血材料的开发，并在体内止血领域引起了广泛关注。本综述概述了多糖的不同形式、止血机制和具体应用。此外，还讨论了基于多糖的止血剂的未来机遇和挑战。
