Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, PR China.
Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, PR China.
Carbohydr Polym. 2022 Sep 1;291:119574. doi: 10.1016/j.carbpol.2022.119574. Epub 2022 May 7.
Unfortunately hemorrhage and its complications (e.g. anemia, organ failure, and hypothermia) induced by traumatic injury, surgery, and disorders of bleeding play an all too familiar role in human morbidity and mortality. Therefore, it is difficult to overstate the importance of better understanding the role of polysaccharides in advanced hemostatic dressings (HDs). This review includes consideration of polysaccharide hemostatic dressing mechanism of action, relative efficacy, cost and safety. Polysaccharide-based HDs are widely used in management not only of external and internal bleeding but also of massive hemorrhage. These polysaccharide-based HDs have been shown to be effective in both compressible and non-compressible hemorrhage. Hemostatic dressings are designed with different principles depending on location and extent of injury. This review focuses on polysaccharide HD design and associated hemostatic mechanisms. It addresses current issues, challenges, and future perspectives.
不幸的是，创伤、手术和出血性疾病引起的出血及其并发症（如贫血、器官衰竭和低体温）在人类发病率和死亡率中扮演着非常熟悉的角色。因此，更好地了解多糖在高级止血敷料（HDs）中的作用的重要性再怎么强调也不为过。本综述包括对多糖止血敷料作用机制、相对疗效、成本和安全性的考虑。基于多糖的 HDs 广泛用于管理不仅是外部和内部出血，而且还管理大出血。这些基于多糖的 HDs 已被证明在可压缩和不可压缩的出血中都有效。止血敷料的设计原则因损伤部位和程度而异。本综述重点介绍多糖 HD 的设计和相关止血机制。它涉及当前的问题、挑战和未来的观点。
