School of Chemical Engineering and Technology, Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin), Tianjin University, Tianjin 300072, China.
Biomater Sci. 2017 Nov 21;5(12):2357-2368. doi: 10.1039/c7bm00554g.
The formation of stable blood clots or hemostasis is essential to prevent major blood loss and death from excessive bleeding. However, the body's own coagulation process is not able to accomplish timely hemostasis without the assistance of hemostatic agents. For developing novel topical hemostatic agents, tissue adhesives and sealants, it is necessary to understand the coagulation process and the hemostasis mechanism of different materials. Among hemostatic materials, polysaccharides are naturally derived polymers having excellent biodegradable and biocompatible properties. This review provides an overview of polysaccharide-based hemostatic materials and agents, including their advantages and drawbacks in hemostatic applications. Furthermore, polysaccharide-based hemostatic materials with anti-microbial and healing functions are also introduced.
形成稳定的血栓或止血对于防止大量失血和因过度出血而导致的死亡至关重要。然而，如果没有止血剂的帮助，身体自身的凝血过程无法及时止血。为了开发新型局部止血剂、组织粘合剂和密封剂，有必要了解不同材料的凝血过程和止血机制。在止血材料中，多糖是具有优异的可生物降解性和生物相容性的天然衍生聚合物。本综述概述了基于多糖的止血材料和制剂，包括它们在止血应用中的优缺点。此外，还介绍了具有抗微生物和愈合功能的基于多糖的止血材料。
